Emerging RAS-directed therapies for cancer.
Ras
erk
inhibition
isoform
pancreatic
signalling
targeted
Journal
Cancer drug resistance (Alhambra, Calif.)
ISSN: 2578-532X
Titre abrégé: Cancer Drug Resist
Pays: United States
ID NLM: 101738710
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
01
2021
revised:
08
03
2021
accepted:
16
03
2021
entrez:
18
5
2022
pubmed:
19
5
2022
medline:
19
5
2022
Statut:
epublish
Résumé
RAS oncogenes are the most commonly mutated oncogenes in human cancer, and RAS-mutant cancers represent a major burden of human disease. Though these oncogenes were discovered decades ago, recent years have seen major advances in understanding of their structure and function, including the therapeutic and prognostic significance of diverse isoforms. Targeting of these mutations has proven difficult, despite some successes with inhibition of RAS effector signalling. More recently, direct RAS inhibition has been achieved in a trial setting. While this has yet to be translated to everyday clinical practice, this development carries much promise. This review summarizes the diverse approaches that have been taken to RAS inhibition and then focuses on the most recent developments in direct inhibition of KRAS(G12C).
Identifiants
pubmed: 35582302
doi: 10.20517/cdr.2021.07
pmc: PMC9094076
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
543-558Informations de copyright
© The Author(s) 2021.
Déclaration de conflit d'intérêts
All authors declared that there are no conflicts of interest.
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