IgG4-associated fibrosing mediastinitis requiring differentiation from posterior mediastinal tumour: A case report.
IgG4‐associated disease
IgG4‐related disease
IgG4‐related fibrosing mediastinitis
fibrosing mediastinitis
posterior mediastinal tumour
Journal
Respirology case reports
ISSN: 2051-3380
Titre abrégé: Respirol Case Rep
Pays: United States
ID NLM: 101631052
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
received:
04
03
2022
accepted:
12
04
2022
entrez:
18
5
2022
pubmed:
19
5
2022
medline:
19
5
2022
Statut:
epublish
Résumé
A 71-year-old man, who was found to have a posterior mediastinal tumour, was referred to our hospital. Contrast-enhanced computed tomography (CT) showed a 15-cm soft tissue shadow in the posterior mediastinum, with many affected areas and a gradually increasing pattern. We also detected oligemic areas with poor contrast-filling. There was no invasion into the adjacent vertebral body and the blood vessels penetrating the interior were intact. Positron emission tomography-CT revealed a high maximum standardized uptake level of 4.53 in the mediastinal masses. We performed thoracoscopic surgery for the biopsy. Histological findings showed lymphoplasmacytic infiltration in the fibrous stroma as well as storiform fibrosis. Immunohistochemical examination revealed abundant infiltration of immunoglobulin G4 (IgG4)-positive plasma cells and 40% IgG4/IgG-positive plasma cells. Postoperative serum examinations showed a high serum IgG4 level (570 mg/dl). Accordingly, we diagnosed the patient with IgG4-related fibrosing mediastinitis, a rare manifestation of IgG4-related disease.
Identifiants
pubmed: 35582341
doi: 10.1002/rcr2.958
pii: RCR2958
pmc: PMC9085914
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e0958Informations de copyright
© 2022 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology.
Déclaration de conflit d'intérêts
None declared.
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