Analyzing single cell transcriptome data from severe COVID-19 patients.
Bioinformatics
Gene Expression
Genomics
Health Sciences
Immunology
Molecular Biology
RNAseq
Journal
STAR protocols
ISSN: 2666-1667
Titre abrégé: STAR Protoc
Pays: United States
ID NLM: 101769501
Informations de publication
Date de publication:
17 06 2022
17 06 2022
Historique:
entrez:
18
5
2022
pubmed:
19
5
2022
medline:
20
5
2022
Statut:
epublish
Résumé
We describe the protocol for identifying COVID-19 severity specific cell types and their regulatory marker genes using single-cell transcriptomics data. We construct COVID-19 comorbid disease-associated gene list using multiple databases and literature resources. Next, we identify specific cell type where comorbid genes are upregulated. We further characterize the identified cell type using gene enrichment analysis. We detect upregulation of marker gene restricted to severe COVID-19 cell type and validate our findings using
Identifiants
pubmed: 35582459
doi: 10.1016/j.xpro.2022.101379
pii: S2666-1667(22)00259-3
pmc: PMC9021126
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101379Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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