Glymphatic system dysfunction in patients with cluster headache.
cluster headache
diffusion tensor imaging
glymphatic system
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
06 2022
06 2022
Historique:
revised:
31
03
2022
received:
07
02
2022
accepted:
03
05
2022
pubmed:
19
5
2022
medline:
28
6
2022
entrez:
18
5
2022
Statut:
ppublish
Résumé
The aim of this study was to investigate alterations of the glymphatic system function in patients with cluster headache. We enrolled patients with cluster headache and healthy controls, and they underwent brain magnetic resonance imaging (MRI), including diffusion tensor imaging (DTI). We used the MRIcron and DSI studio programs for DTI preprocessing and DTI analysis with perivascular space (DTI-ALPS) index calculation. Fourteen patients with cluster headache and 23 healthy controls were enrolled. The DTI-ALPS indexes of the groups were significantly different. The DTI-ALPS index for the patients with cluster headache was lower than that for the healthy controls (1.586 vs. 1.786, p = 0.044). There was a significant negative correlation between the DTI-ALPS index and age in the patients with cluster headache (r = -0.549, p = 0.042). However, the DTI-ALPS index was not associated with other clinical characteristics, including disease duration and headache intensity (r = -0.405, p = 0.150; r = -0.048, p = 0.869, respectively). Patients with cluster headache had a lower DTI-ALPS index than the healthy controls; this might indicate glymphatic system dysfunction in the patients with cluster headache. Further research is required to determine whether glymphatic system dysfunction is related to the pathophysiology of cluster headache.
Identifiants
pubmed: 35582786
doi: 10.1002/brb3.2631
pmc: PMC9226822
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2631Informations de copyright
© 2022 The Authors. Brain and Behavior published by Wiley Periodicals LLC.
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