Demand and usage of unrelated donor products for allogeneic haematopoietic cell transplantation during the COVID-19 pandemic: A Canadian Blood Services Stem Cell Registry analysis.
COVID-19
cord blood
donor usage
haematopoietic cell transplantation
pandemic
unrelated donor
Journal
Vox sanguinis
ISSN: 1423-0410
Titre abrégé: Vox Sang
Pays: England
ID NLM: 0413606
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
revised:
31
03
2022
received:
21
12
2021
accepted:
27
04
2022
pubmed:
19
5
2022
medline:
15
9
2022
entrez:
18
5
2022
Statut:
ppublish
Résumé
Understanding changes in the demand and usage of unrelated allogeneic haematopoietic cell transplantation (HCT) donors during the COVID-19 pandemic is needed to optimize pandemic preparedness of registry and donor collection services. The aim of this study was to understand the extent to which the pandemic has impacted the demand and usage of unrelated donors and cord blood units (CBUs) at Canadian Blood Services (CBS). Data regarding stem cell donor interest and product usage for unrelated allogeneic HCT were retrieved from the database at CBS using de-identified anonymous information. Unrelated donor searches for Canadian patients remained unchanged by the pandemic, reflecting stable demand. The number of unrelated allogeneic transplants performed within Canada also remained stable, while the number of cord blood transplants increased, chiefly for paediatric patients. Requests for donor verification typing, a first signal of potential interest, increased from domestic centres during the first 6 months of the pandemic and decreased from international centres, before returning to baseline levels. The proportion of transplants for Canadian patients who used stem cell products procured from Canadian donors increased between 3 and 6 months after the start of the pandemic before returning to baseline and appears to be increasing again more than 1 year after the start of the pandemic. Use of CBUs for Canadian paediatric patients increased and remains elevated. Demand for unrelated adult HCT donors has remained stable despite the evolving pandemic with a transient and recurring increased interest and usage of domestic adult donors. Use of CBUs for paediatric patients has increased and remains elevated. Registries and donor collection centres should maintain the capacity to expand services for domestic donor collection during pandemics to offset threats to international donor usage.
Sections du résumé
BACKGROUND AND OBJECTIVES
OBJECTIVE
Understanding changes in the demand and usage of unrelated allogeneic haematopoietic cell transplantation (HCT) donors during the COVID-19 pandemic is needed to optimize pandemic preparedness of registry and donor collection services. The aim of this study was to understand the extent to which the pandemic has impacted the demand and usage of unrelated donors and cord blood units (CBUs) at Canadian Blood Services (CBS).
MATERIALS AND METHODS
METHODS
Data regarding stem cell donor interest and product usage for unrelated allogeneic HCT were retrieved from the database at CBS using de-identified anonymous information.
RESULTS
RESULTS
Unrelated donor searches for Canadian patients remained unchanged by the pandemic, reflecting stable demand. The number of unrelated allogeneic transplants performed within Canada also remained stable, while the number of cord blood transplants increased, chiefly for paediatric patients. Requests for donor verification typing, a first signal of potential interest, increased from domestic centres during the first 6 months of the pandemic and decreased from international centres, before returning to baseline levels. The proportion of transplants for Canadian patients who used stem cell products procured from Canadian donors increased between 3 and 6 months after the start of the pandemic before returning to baseline and appears to be increasing again more than 1 year after the start of the pandemic. Use of CBUs for Canadian paediatric patients increased and remains elevated.
CONCLUSION
CONCLUSIONS
Demand for unrelated adult HCT donors has remained stable despite the evolving pandemic with a transient and recurring increased interest and usage of domestic adult donors. Use of CBUs for paediatric patients has increased and remains elevated. Registries and donor collection centres should maintain the capacity to expand services for domestic donor collection during pandemics to offset threats to international donor usage.
Identifiants
pubmed: 35583125
doi: 10.1111/vox.13294
pmc: PMC9347538
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1121-1125Subventions
Organisme : None declared.
Informations de copyright
© 2022 International Society of Blood Transfusion.
Références
Bone Marrow Transplant. 2022 Jan;57(1):125-127
pubmed: 34621021
Transplant Cell Ther. 2021 May;27(5):438.e1-438.e6
pubmed: 33728417
Med J Aust. 2020 Jun;212(10):481-489
pubmed: 32401360
Bone Marrow Transplant. 2021 Apr;56(4):798-806
pubmed: 33219340
Biol Blood Marrow Transplant. 2020 Dec;26(12):2181-2189
pubmed: 32717432
Transfusion. 2021 Jan;61(1):24-28
pubmed: 33084098
Transplant Cell Ther. 2021 Feb;27(2):133-141
pubmed: 33830022
Transfusion. 2017 Nov;57(11):2782-2789
pubmed: 28963719
Transfusion. 2019 Jul;59(7):2382-2388
pubmed: 31002398
Transplant Cell Ther. 2021 Jun;27(6):507-516
pubmed: 33865804
Transplant Cell Ther. 2021 Jun;27(6):446-447
pubmed: 34144791
Vox Sang. 2022 Sep;117(9):1121-1125
pubmed: 35583125
Biol Blood Marrow Transplant. 2020 Nov;26(11):e298-e299
pubmed: 32822844
Bone Marrow Transplant. 2020 Oct;55(10):2043-2044
pubmed: 32203269
Bone Marrow Transplant. 2021 Oct;56(10):2489-2496
pubmed: 34127808