Intraductal tubulopapillary neoplasm (ITPN) of the pancreas: a distinct entity among pancreatic tumors.


Journal

Histopathology
ISSN: 1365-2559
Titre abrégé: Histopathology
Pays: England
ID NLM: 7704136

Informations de publication

Date de publication:
Sep 2022
Historique:
revised: 03 05 2022
received: 29 12 2021
accepted: 16 05 2022
pubmed: 19 5 2022
medline: 11 8 2022
entrez: 18 5 2022
Statut: ppublish

Résumé

Intraductal tubulopapillary neoplasm (ITPN) of the pancreas is a recently recognized pancreatic tumor entity. Here we aimed to determine the most important features with a systematic review coupled with an integrated statistical approach. PubMed, SCOPUS, and Embase were searched for studies reporting data on pancreatic ITPN. The clinicopathological, immunohistochemical, and molecular data were summarized. Then a comprehensive survival analysis and a comparative analysis of the molecular alterations of ITPN with those of pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) from reference cohorts (including the International Cancer Genome Consortium- ICGC dataset and The Cancer Genome Atlas, TCGA program) were conducted. The core findings of 128 patients were as follows: (i) Clinicopathological parameters: pancreatic head is the most common site; presence of an associated adenocarcinoma was reported in 60% of cases, but with rare nodal metastasis. (ii) Immunohistochemistry: MUC1 (>90%) and MUC6 (70%) were the most frequently expressed mucins. ITPN lacked the intestinal marker MUC2; unlike IPMN, it did not express MUC5AC. (iii) Molecular landscape: Compared with PDAC/IPMN, the classic pancreatic drivers KRAS, TP53, CDKN2A, SMAD4, GNAS, and RNF43 were less altered in ITPN (P < 0.001), whereas MCL amplifications, FGFR2 fusions, and PI3KCA mutations were commonly altered (P < 0.001). (iv) Survival analysis: ITPN with a "pure" branch duct involvement showed the lowest risk of recurrence. ITPN is a distinct pancreatic neoplasm with specific clinicopathological and molecular characteristics. Its recognition is fundamental for its clinical/prognostic implications and for the enrichment of potential targets for precision oncology.

Identifiants

pubmed: 35583805
doi: 10.1111/his.14698
pmc: PMC9544156
doi:

Types de publication

Journal Article Review Systematic Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

297-309

Subventions

Organisme : Fondazione Cassa di Risparmio di Verona Vicenza Belluno e Ancona
ID : 203885/2017
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 26343
Organisme : Fondazione Cariverona
Organisme : Fondazione Italiana Malattie Pancreas
ID : FIMP- J38D19000690001
Organisme : Italian Ministry of Health
ID : RF CO-2019-12369662: CUP: B39C21000370001
Organisme : Ministry of Health
ID : B39C21000370001
Organisme : Ministry of Health
ID : J38D19000690001
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States

Informations de copyright

© 2022 The Authors. Histopathology published by John Wiley & Sons Ltd.

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Auteurs

Gaetano Paolino (G)

Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy.

Irene Esposito (I)

Institute of Pathology, University Hospital of Duesseldorf, Duesseldorf, Germany.

Seung-Mo Hong (SM)

Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Olca Basturk (O)

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Paola Mattiolo (P)

Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy.

Takuma Kaneko (T)

Department of Hepato-Biliary-Pancreatic Medicine, NTT Medical Center, Tokyo, Japan.

Nicola Veronese (N)

Department of Internal Medicine, University of Palermo, Palermo, Italy.

Aldo Scarpa (A)

Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy.
ARC-Net Research Center, University and Hospital Trust of Verona, Verona, Italy.

Volkan Adsay (V)

Department of Pathology, Koç University Hospital and Koç University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.

Claudio Luchini (C)

Department of Diagnostics and Public Health, Section of Pathology, University and Hospital Trust of Verona, Verona, Italy.
ARC-Net Research Center, University and Hospital Trust of Verona, Verona, Italy.

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