Intraductal tubulopapillary neoplasm (ITPN) of the pancreas: a distinct entity among pancreatic tumors.
IPMN
ITPN
PDAC
intraductal
pancreas
pancreatic ductal adenocarcinoma
tubulopapillary
Journal
Histopathology
ISSN: 1365-2559
Titre abrégé: Histopathology
Pays: England
ID NLM: 7704136
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
revised:
03
05
2022
received:
29
12
2021
accepted:
16
05
2022
pubmed:
19
5
2022
medline:
11
8
2022
entrez:
18
5
2022
Statut:
ppublish
Résumé
Intraductal tubulopapillary neoplasm (ITPN) of the pancreas is a recently recognized pancreatic tumor entity. Here we aimed to determine the most important features with a systematic review coupled with an integrated statistical approach. PubMed, SCOPUS, and Embase were searched for studies reporting data on pancreatic ITPN. The clinicopathological, immunohistochemical, and molecular data were summarized. Then a comprehensive survival analysis and a comparative analysis of the molecular alterations of ITPN with those of pancreatic ductal adenocarcinoma (PDAC) and intraductal papillary mucinous neoplasm (IPMN) from reference cohorts (including the International Cancer Genome Consortium- ICGC dataset and The Cancer Genome Atlas, TCGA program) were conducted. The core findings of 128 patients were as follows: (i) Clinicopathological parameters: pancreatic head is the most common site; presence of an associated adenocarcinoma was reported in 60% of cases, but with rare nodal metastasis. (ii) Immunohistochemistry: MUC1 (>90%) and MUC6 (70%) were the most frequently expressed mucins. ITPN lacked the intestinal marker MUC2; unlike IPMN, it did not express MUC5AC. (iii) Molecular landscape: Compared with PDAC/IPMN, the classic pancreatic drivers KRAS, TP53, CDKN2A, SMAD4, GNAS, and RNF43 were less altered in ITPN (P < 0.001), whereas MCL amplifications, FGFR2 fusions, and PI3KCA mutations were commonly altered (P < 0.001). (iv) Survival analysis: ITPN with a "pure" branch duct involvement showed the lowest risk of recurrence. ITPN is a distinct pancreatic neoplasm with specific clinicopathological and molecular characteristics. Its recognition is fundamental for its clinical/prognostic implications and for the enrichment of potential targets for precision oncology.
Identifiants
pubmed: 35583805
doi: 10.1111/his.14698
pmc: PMC9544156
doi:
Types de publication
Journal Article
Review
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
297-309Subventions
Organisme : Fondazione Cassa di Risparmio di Verona Vicenza Belluno e Ancona
ID : 203885/2017
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 26343
Organisme : Fondazione Cariverona
Organisme : Fondazione Italiana Malattie Pancreas
ID : FIMP- J38D19000690001
Organisme : Italian Ministry of Health
ID : RF CO-2019-12369662: CUP: B39C21000370001
Organisme : Ministry of Health
ID : B39C21000370001
Organisme : Ministry of Health
ID : J38D19000690001
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Informations de copyright
© 2022 The Authors. Histopathology published by John Wiley & Sons Ltd.
Références
Am J Surg Pathol. 2007 Mar;31(3):363-70
pubmed: 17325477
Diagn Interv Radiol. 2019 Jul;25(4):251-256
pubmed: 31147310
Pathol Int. 2009 Jan;59(1):53-8
pubmed: 19121093
Cureus. 2020 Jun 10;12(6):e8548
pubmed: 32670685
World J Surg Oncol. 2017 Nov 16;15(1):203
pubmed: 29145864
Diagn Cytopathol. 2014 Feb;42(2):156-60
pubmed: 22807417
Clin J Gastroenterol. 2012 Dec;5(6):413-20
pubmed: 26181322
Endoscopy. 2017 Nov;49(11):E266-E267
pubmed: 28772325
Ann Surg. 2016 Jan;263(1):162-77
pubmed: 25775066
Gastric Cancer. 2021 Nov;24(6):1169-1183
pubmed: 34398359
BMC Gastroenterol. 2021 Apr 13;21(1):162
pubmed: 33849435
Cancers (Basel). 2021 Jun 01;13(11):
pubmed: 34205964
Surg Case Rep. 2020 Aug 14;6(1):210
pubmed: 32797315
BMJ. 2009 Jul 21;339:b2700
pubmed: 19622552
Postgrad Med. 2020 Apr;132(3):270-273
pubmed: 31524017
J Gastroenterol. 2006 Jul;41(7):702-5
pubmed: 16933009
Am J Surg Pathol. 2017 Mar;41(3):313-325
pubmed: 27984235
J Pathol. 2013 Nov;231(3):335-41
pubmed: 23893889
Int J Clin Exp Pathol. 2015 Aug 01;8(8):9672-80
pubmed: 26464736
Int J Clin Exp Pathol. 2019 Mar 01;12(3):1041-1046
pubmed: 31933917
Int J Surg Case Rep. 2019;55:187-191
pubmed: 30753991
Am J Surg Pathol. 2011 Dec;35(12):1812-7
pubmed: 21945955
Am J Gastroenterol. 2021 May 1;116(5):867
pubmed: 32740089
Gut. 2018 May;67(5):789-804
pubmed: 29574408
Int Surg. 2015 Feb;100(2):281-6
pubmed: 25692431
Pathol Int. 2007 Nov;57(11):741-5
pubmed: 17922686
Int J Surg Case Rep. 2020;76:492-496
pubmed: 33207417
Int J Surg Case Rep. 2018;48:122-125
pubmed: 29906691
Korean J Radiol. 2008 Sep-Oct;9(5):473-6
pubmed: 18838860
Nat Rev Gastroenterol Hepatol. 2021 Jul;18(7):457-468
pubmed: 34099908
Mod Pathol. 2017 Dec;30(12):1760-1772
pubmed: 28776573
CA Cancer J Clin. 2021 May;71(3):209-249
pubmed: 33538338
Pancreas. 2018 May/Jun;47(5):544-550
pubmed: 29702531
Medicine (Baltimore). 2019 Feb;98(6):e14426
pubmed: 30732200
Oncol Res Treat. 2018;41(10):603-610
pubmed: 30269131
Cancer Treat Rev. 2015 Sep;41(8):707-13
pubmed: 26138515
Abdom Radiol (NY). 2021 Aug;46(8):3946-3962
pubmed: 33742217
Nat Commun. 2020 Sep 10;11(1):4527
pubmed: 32913197
Curr Oncol Rep. 2021 Jul 16;23(9):108
pubmed: 34269915
Diagn Pathol. 2014 Jan 20;9:11
pubmed: 24443801
Gastrointest Endosc. 2005 Feb;61(2):325-9
pubmed: 15729258
Surg Case Rep. 2018 Aug 16;4(1):96
pubmed: 30116990
Diagn Cytopathol. 2015 Dec;43(12):1003-6
pubmed: 26390029
Pathology. 2015 Feb;47(2):169-71
pubmed: 25551309
Fam Cancer. 2014 Jun;13(2):227-9
pubmed: 24317685
Gastroenterol Clin Biol. 2006 Nov;30(11):1301-4
pubmed: 17185972
Lancet. 2020 Jun 27;395(10242):2008-2020
pubmed: 32593337
World J Surg Oncol. 2018 Apr 24;16(1):83
pubmed: 29690869
Am J Surg Pathol. 2009 Aug;33(8):1164-72
pubmed: 19440145
Surg Case Rep. 2019 Feb 19;5(1):33
pubmed: 30783809
Am J Surg Pathol. 1999 Feb;23(2):227-31
pubmed: 9989851
Pathol Int. 2012 May;62(5):339-43
pubmed: 22524663
Gastrointest Endosc. 2020 Oct;92(4):967-968
pubmed: 32376333
Am J Case Rep. 2020 Jul 10;21:e924760
pubmed: 32647104
Pancreas. 2004 Aug;29(2):116-22
pubmed: 15257103
Acta Cytol. 2016;60(3):267-74
pubmed: 27459312
Pathol Res Pract. 2012 Nov 15;208(11):691-6
pubmed: 23057996
Clin J Gastroenterol. 2019 Apr;12(2):153-159
pubmed: 30284703
Langenbecks Arch Surg. 2016 Jun;401(4):439-47
pubmed: 27001682
Am Surg. 2018 Sep 1;84(9):e395-e397
pubmed: 30454511
JAMA. 2000 Apr 19;283(15):2008-12
pubmed: 10789670
Arch Pathol Lab Med. 2019 Nov;143(11):1317-1326
pubmed: 31509453
J Dig Dis. 2015 Jun;16(6):357-61
pubmed: 25761758
Mol Clin Oncol. 2017 May;6(5):676-682
pubmed: 28529742
Gastrointest Endosc. 2002 Sep;56(3):441-4
pubmed: 12196793
Clin Transl Oncol. 2016 Jun;18(6):541-9
pubmed: 26510854
Virchows Arch. 2002 Feb;440(2):205-208
pubmed: 11964052
Nat Commun. 2018 Dec 17;9(1):5341
pubmed: 30559424
Cancer Cell. 2017 Aug 14;32(2):185-203.e13
pubmed: 28810144
Clin Nucl Med. 2014 Apr;39(4):e277-80
pubmed: 23676658
Endoscopy. 2021 Sep;53(9):E345-E347
pubmed: 33175997
Virchows Arch. 2004 May;444(5):447-53
pubmed: 15014986
Pancreatology. 2021 May 5;:
pubmed: 33994068
Diagn Cytopathol. 2014 Apr;42(4):314-20
pubmed: 24339429
J Clin Diagn Res. 2017 Sep;11(9):PD14-PD16
pubmed: 29207779
World J Gastrointest Oncol. 2018 Oct 15;10(10):317-327
pubmed: 30364837
Case Rep Gastroenterol. 2017 Nov 2;11(3):661-666
pubmed: 29282388
Oncol Lett. 2017 Jul;14(1):153-158
pubmed: 28693147
J Comput Assist Tomogr. 2012 Nov-Dec;36(6):710-7
pubmed: 23192209
Am J Gastroenterol. 1996 Apr;91(4):798-800
pubmed: 8677955
Pathol Int. 2015 Sep;65(9):501-6
pubmed: 26119268
Diagn Pathol. 2014 Sep 23;9:172
pubmed: 25245835
BMJ Case Rep. 2011 Dec 08;2011:
pubmed: 22669886
APMIS. 2019 Jan;127(1):27-32
pubmed: 30549137
Hepatobiliary Surg Nutr. 2020 Aug;9(4):562-563
pubmed: 32832521
Cancer. 2002 Jan 1;94(1):62-77
pubmed: 11815961
J Nippon Med Sch. 2013;80(3):224-9
pubmed: 23832407