Bisindolylmaleimide Ligands Stabilize


Journal

Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623

Informations de publication

Date de publication:
07 06 2022
Historique:
pubmed: 19 5 2022
medline: 9 6 2022
entrez: 18 5 2022
Statut: ppublish

Résumé

G-Quadruplex (G4) structures play a pivotal role in diverse biological functions, including essential processes, such as telomere maintenance and gene regulation. G4 structures formed in functional regions of genomes are actively pursued toward therapeutics and are targeted by small-molecule ligands that alter their structure and/or stability. Herein, we report the synthesis of bisindolylmaleimide-based (

Identifiants

pubmed: 35584037
doi: 10.1021/acs.biochem.2c00116
doi:

Substances chimiques

Indoles 0
Ligands 0
Maleimides 0
DNA 9007-49-2
bisindolylmaleimide MBK3OO5K8T

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1064-1076

Auteurs

Satendra Kumar (S)

Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.

Rajesh Kumar Reddy Sannapureddi (RK)

Department of Chemistry, Indian Institute of Science Education and Research, Bhopal 462066, India.

Chaitra S Todankar (CS)

Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.

R Ramanathan (R)

Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.

Annyesha Biswas (A)

Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.

Bharathwaj Sathyamoorthy (B)

Department of Chemistry, Indian Institute of Science Education and Research, Bhopal 462066, India.

P I Pradeepkumar (PI)

Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.

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Classifications MeSH