Bizonal cardiac engineered tissues with differential maturation features in a mid-throughput multimodal bioreactor.

Bioengineering Biological sciences Biotechnology Cell biology Tissue engineering

Journal

iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038

Informations de publication

Date de publication:
20 May 2022
Historique:
received: 19 04 2021
revised: 26 11 2021
accepted: 21 04 2022
entrez: 19 5 2022
pubmed: 20 5 2022
medline: 20 5 2022
Statut: epublish

Résumé

Functional three-dimensional (3D) engineered cardiac tissue (ECT) models are essential for effective drug screening and biological studies. Application of physiological cues mimicking those typical of the native myocardium is known to promote the cardiac maturation and functionality

Identifiants

pubmed: 35586070
doi: 10.1016/j.isci.2022.104297
pii: S2589-0042(22)00567-3
pmc: PMC9108516
doi:

Types de publication

Journal Article

Langues

eng

Pagination

104297

Informations de copyright

© 2022 The Authors.

Déclaration de conflit d'intérêts

The authors declare no competing interests. For full transparency policy, the authors A.P., A.M., and G.I. declare to hold a patent (number: EP19165964) covering the design of the presented bioreactor. Updated list of the current institutional affiliations of some of the authors:-Alessia Pisanu, Nobel Biocare, Zürich-Flughafen, Switzerland-Diana Robles Diaz, Novartis International, AG, Basel, Switzerland-Hadi Tarhini, Northvolt, Västerås, Sweden-Giuseppe Isu: Medics3D, Torino, Italy

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Auteurs

Alessia Pisanu (A)

Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.
Department of Surgery, University Hospital of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

Gregory Reid (G)

Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.
Department of Surgery, University Hospital of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

Deborah Fusco (D)

Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.
Department of Surgery, University Hospital of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

Antonio Sileo (A)

Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.
Department of Surgery, University Hospital of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

Diana Robles Diaz (D)

Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.
Department of Surgery, University Hospital of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

Hadi Tarhini (H)

PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.

Giovanni Putame (G)

PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.

Diana Massai (D)

PolitoBIOMed Lab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin, Italy.

Giuseppe Isu (G)

Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.
Department of Surgery, University Hospital of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

Anna Marsano (A)

Department of Biomedicine, University of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.
Department of Surgery, University Hospital of Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

Classifications MeSH