Delayed Neuropsychiatric Sequel Following Pediatric Carbon Monoxide Poisoning: A Case Report and Literature Review.
carbon monoxide poisoning
delayed neurological sequel
delayed neuropsychiatric sequel
encephalopathy
neurological disorders
seizure
Journal
Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
01
2022
accepted:
24
03
2022
entrez:
19
5
2022
pubmed:
20
5
2022
medline:
20
5
2022
Statut:
epublish
Résumé
Carbon monoxide (CO) poisoning is a serious health problem. The main pathophysiological mechanism of acute CO poisoning is hypoxia due to the formation of carboxyhemoglobin (COHb). Delayed neuropsychiatric sequel (DNPS) occurs following an interval of several days to several weeks post-CO exposure and can present in many different manifestations, ranging from behavioral and mood disorders to encephalopathy and seizures and cause long-term neuropsychiatric sequel. The pathogenesis of DNPS following CO poisoning is a complex one that encompasses hypoxia-induced encephalopathy as well as inflammation, direct cellular changes and damage. The incidence varies and treatment is debated. We display a case of a previously healthy 13-year-old boy suffering from DNPS, presenting with seizures and encephalopathy and later developing optic nerve damage. Increased awareness to this condition might help diagnose future patients and aid in the understanding of the pathogenesis and treatment options for this poorly understood condition.
Identifiants
pubmed: 35586831
doi: 10.3389/fped.2022.861254
pmc: PMC9108491
doi:
Types de publication
Case Reports
Langues
eng
Pagination
861254Informations de copyright
Copyright © 2022 Gavrieli, Noyman, Hershkovitz, Taragin and Hazan.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Chin Med Assoc. 2018 Aug;81(8):682-690
pubmed: 29853349
Toxicol Ind Health. 2011 Jun;27(5):397-406
pubmed: 21088053
Proc Natl Acad Sci U S A. 2004 Sep 14;101(37):13660-5
pubmed: 15342916
Pediatr Emerg Care. 2016 May;32(5):303-6
pubmed: 26011807
Brain Inj. 2006 Mar;20(3):273-81
pubmed: 16537269
Undersea Hyperb Med. 2020 First Quarter;47(1):151-169
pubmed: 32176957
Toxicol Appl Pharmacol. 2006 Jun 1;213(2):152-9
pubmed: 16325878
Pediatr Neonatol. 2017 Apr;58(2):171-177
pubmed: 27502424
Drug Des Devel Ther. 2020 Apr 02;14:1333-1339
pubmed: 32308366
Drug Des Devel Ther. 2017 Feb 23;11:513-519
pubmed: 28260864
Brain Dev. 2007 Apr;29(3):174-7
pubmed: 17008041
N Engl J Med. 2002 Oct 3;347(14):1057-67
pubmed: 12362006
J Child Neurol. 2006 Sep;21(9):737-41
pubmed: 16970876
Int J Emerg Med. 2020 Dec 2;13(1):61
pubmed: 33267798
Brain Behav Immun Health. 2021 Nov 27;18:100398
pubmed: 34917988
Neurotoxicology. 2015 May;48:35-43
pubmed: 25757834
Am J Respir Crit Care Med. 2017 Mar 1;195(5):596-606
pubmed: 27753502
Intensive Care Med. 2011 Mar;37(3):486-92
pubmed: 21125215
Brain Res. 2019 May 1;1710:22-32
pubmed: 30578768
Am J Respir Crit Care Med. 2012 Dec 1;186(11):1095-101
pubmed: 23087025
Peptides. 2014 Sep;59:89-93
pubmed: 25038511
N Engl J Med. 2009 Mar 19;360(12):1217-25
pubmed: 19297574