Why you always in a mood? Pumpin' polyP, actin' brand new.

Actins Amyotrophic Lateral Sclerosis Cell Death Humans Neurodegenerative Diseases Neurons

Journal

Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320

Informations de publication

Date de publication:
18 05 2022
Historique:
entrez: 19 5 2022
pubmed: 20 5 2022
medline: 24 5 2022
Statut: ppublish

Résumé

What causes neurons to die in neurodegenerative disease? In this issue of Neuron, Arredondo et al., 2022 report an unexpected culprit that may drive neuronal death in amyotrophic lateral sclerosis-an evolutionarily ancient energy-storage polymer called polyphosphate (polyP).

Identifiants

DOI: 10.1016/j.neuron.2022.04.003 PMID: 35588711
pubmed: 35588711
pii: S0896-6273(22)00311-7
doi: 10.1016/j.neuron.2022.04.003
pii:
doi:

Substances chimiques

Actins 0

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

1603-1605

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests A.D.G. is a scientific founder of Maze Therapeutics.

Auteurs

Kevin A Guttenplan (KA)

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA.

Aaron D Gitler (AD)

Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: agitler@stanford.edu.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Actines › Why you always in a mood? Pumpin' polyP,...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Protéinopathies TDP-43 › Sclérose latérale amyotrophique › Why you always in a mood? Pumpin' polyP,...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Why you always in a mood? Pumpin' polyP,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Why you always in a mood? Pumpin' polyP,...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Why you always in a mood? Pumpin' polyP,...
questionsmedicales.fr › Cellules › Neurones › Why you always in a mood? Pumpin' polyP,...