Toll-like Interleukin -1 Receptor Regulator (TILRR) Protein, a Major Modulator of Inflammation, is Expressed in Normal Human and Macaque Tissues and PBMCs.
PBMCs
TILRR
cynomolgus monkey (Macaca fascicularis)
human
inflammation
rhesus monkey (Macaca mulatta)
tissues
Journal
Journal of inflammation research
ISSN: 1178-7031
Titre abrégé: J Inflamm Res
Pays: New Zealand
ID NLM: 101512684
Informations de publication
Date de publication:
2022
2022
Historique:
received:
08
02
2022
accepted:
27
04
2022
entrez:
20
5
2022
pubmed:
21
5
2022
medline:
21
5
2022
Statut:
epublish
Résumé
TILRR is a modulator of genes in the NF-κB inflammation pathway. It regulates inflammation-responsive genes, the secretion of inflammatory mediators, and the migration of immune cells. Because inflammation drives the pathogenesis of many infectious and inflammatory diseases, it is important to know the expression of TILRR protein in tissues and cells. This study examined TILRR protein expression in healthy adult human and macaques' tissues and PBMCs (peripheral blood mononuclear cells). Tissues (trachea, lungs, stomach, small intestine [ileum], cecum, colon, rectum, vagina, cervix, uterus, and penis) and PBMCs from humans and macaques were lysed in RIPA (radioimmunoprecipitation assay) lysis buffer. The TILRR protein was examined by fluorescent Western blot analysis. The relative fluorescence units (rfu) of TILRR protein expression were quantified by Image Studio software (LI-COR). The results showed that adult healthy female (n=1) rectal and cervicovaginal tissues expressed a higher level of TILRR protein than the other tissues (trachea, lungs, stomach, small intestine [ileum], cecum, colon, uterus, and penis) examined. Like humans, the lungs, colon, and rectal tissues of healthy adult female cynomolgus monkeys ( Our study for the first time showed that TILRR protein is expressed in healthy adult human and monkey tissues and PBMCs. The TILRR protein in these tissues and PBMCs may play a role in the inflammatory response of these tissues and cells in response to infectious pathogens.
Identifiants
pubmed: 35592073
doi: 10.2147/JIR.S357866
pii: 357866
pmc: PMC9113122
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2925-2937Informations de copyright
© 2022 Kashem et al.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
J Med Primatol. 2017 Aug;46(4):137-143
pubmed: 28748659
Sci Rep. 2016 May 05;6:25359
pubmed: 27146253
Hum Reprod. 2005 Jun;20(6):1439-46
pubmed: 15734755
Microbes Infect. 2011 Jan;13(1):58-64
pubmed: 20955815
Lab Invest. 1985 Nov;53(5):586-8
pubmed: 2997545
Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):
pubmed: 34625475
JACC Basic Transl Sci. 2017 Aug 28;2(4):398-414
pubmed: 28920098
Self Nonself. 2010 Oct;1(4):299-309
pubmed: 21487504
Lancet. 2003 Jul 26;362(9380):263-70
pubmed: 12892955
J Biol Chem. 2010 Mar 5;285(10):7222-32
pubmed: 19940113
PLoS One. 2017 Oct 5;12(10):e0186079
pubmed: 28982126
Mucosal Immunol. 2016 Jan;9(1):194-205
pubmed: 26104913
Sci Rep. 2019 Jun 10;9(1):8378
pubmed: 31182764
Ann N Y Acad Sci. 1994 May 28;725:128-45
pubmed: 8030984
Oncotarget. 2017 Dec 14;9(6):7204-7218
pubmed: 29467962
J Virol. 2019 Oct 15;93(21):
pubmed: 31413132
Vaccine. 2015 Jun 17;33(27):3073-83
pubmed: 25510387
PLoS One. 2018 Aug 28;13(8):e0202997
pubmed: 30153293
Nat Rev Immunol. 2009 Oct;9(10):717-28
pubmed: 19859066
Clin Exp Gastroenterol. 2019 Jul 19;12:321-329
pubmed: 31410046
Methods Mol Biol. 2016;1304:53-61
pubmed: 25092056
Aging (Albany NY). 2020 Oct 8;12(19):19335-19351
pubmed: 33031059
BMC Immunol. 2015 Aug 26;16:48
pubmed: 26307036
Front Immunol. 2019 Feb 28;10:272
pubmed: 30873160
Bioinformation. 2018 Feb 28;14(2):48-52
pubmed: 29618899
PLoS One. 2016 Feb 09;11(2):e0148186
pubmed: 26859579
Cell Mol Life Sci. 2016 Nov;73(22):4203-4212
pubmed: 27271753
AIDS. 1990 Aug;4(8):783-9
pubmed: 1979745
J Inflamm Res. 2009;2:1-11
pubmed: 22096348
Nat Med. 2006 Oct;12(10):1203-7
pubmed: 16964257
Clin Infect Dis. 2015 Jul 15;61(2):260-9
pubmed: 25900168
Curr Protoc Immunol. 2009 Apr;Chapter 7:Unit7.1
pubmed: 19347849
Rheumatology (Oxford). 2004 Mar;43(3):294-301
pubmed: 14679293
Monoclon Antib Immunodiagn Immunother. 2014 Apr;33(2):129-40
pubmed: 24746155
Nat Immunol. 2005 Dec;6(12):1182-90
pubmed: 16369557
Front Immunol. 2018 Oct 05;9:2193
pubmed: 30344519
Front Cell Dev Biol. 2020 Feb 25;8:99
pubmed: 32161756
Front Immunol. 2020 Jun 16;11:1441
pubmed: 32612615
Front Cell Dev Biol. 2020 Jul 03;8:563
pubmed: 32719797
Int J Mol Sci. 2021 Jul 22;22(15):
pubmed: 34360591
J Infect Dis. 1991 Feb;163(2):233-9
pubmed: 1988508
EBioMedicine. 2022 Apr;78:103955
pubmed: 35339895
J Inflamm Res. 2021 Sep 24;14:4927-4943
pubmed: 34594127
Cells. 2021 Jan 09;10(1):
pubmed: 33435303
Curr Opin HIV AIDS. 2016 Mar;11(2):156-62
pubmed: 26628324
J Clin Invest. 2019 Apr 1;129(4):1441-1451
pubmed: 30932910
ILAR J. 2008;49(2):220-55
pubmed: 18323583
FASEB J. 1994 Oct;8(13):1041-7
pubmed: 7926369
JACC Basic Transl Sci. 2017 Aug 28;2(4):415-417
pubmed: 30062159
Cancer Immunol Res. 2013 Aug;1(2):77-84
pubmed: 24777498
Nat Med. 2020 Oct;26(10):1636-1643
pubmed: 32839624
Expert Rev Vaccines. 2008 Nov;7(9):1419-34
pubmed: 18980543