Associations between Suicidal Thoughts and Behaviors and Genetic Liability for Cognitive Performance, Depression, and Risk-Taking in a High-Risk Sample.
Cognitive function
Depression
GWAS
Impulsivity
Polygenic risk scores
Suicide
Journal
Complex psychiatry
ISSN: 2673-3005
Titre abrégé: Complex Psychiatry
Pays: Switzerland
ID NLM: 101764441
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
04
02
2021
accepted:
11
05
2021
entrez:
20
5
2022
pubmed:
21
5
2022
medline:
21
5
2022
Statut:
ppublish
Résumé
Suicidal thoughts and behaviors (STBs) and nonsuicidal self-injury (NSSI) behaviors are moderately heritable and may reflect an underlying predisposition to depression, impulsivity, and cognitive vulnerabilities to varying degrees. We aimed to estimate the degrees of association between genetic liability to depression, impulsivity, and cognitive performance and STBs and NSSI in a high-risk sample. We used data on 7,482 individuals of European ancestry and 3,359 individuals of African ancestry from the Collaborative Study on the Genetics of Alcoholism to examine the links between polygenic scores (PGSs) for depression, impulsivity/risk-taking, and cognitive performance with 3 self-reported indices of STBs (suicidal ideation, persistent suicidal ideation defined as ideation occurring on at least 7 consecutive days, and suicide attempt) and with NSSI. The PGS for depression was significantly associated with all 4 primary self-harm measures, explaining 0.6-2.5% of the variance. The PGS for risk-taking behaviors was also associated with all 4 self-harm behaviors in baseline models, but was no longer associated after controlling for a lifetime measure of DSM-IV alcohol dependence and abuse symptom counts. Polygenic predisposition for cognitive performance was negatively associated with suicide attempts ( Our results encourage the study of STB as transdiagnostic outcomes that show genetic overlap with a range of risk factors.
Sections du résumé
Background
UNASSIGNED
Suicidal thoughts and behaviors (STBs) and nonsuicidal self-injury (NSSI) behaviors are moderately heritable and may reflect an underlying predisposition to depression, impulsivity, and cognitive vulnerabilities to varying degrees.
Objectives
UNASSIGNED
We aimed to estimate the degrees of association between genetic liability to depression, impulsivity, and cognitive performance and STBs and NSSI in a high-risk sample.
Methods
UNASSIGNED
We used data on 7,482 individuals of European ancestry and 3,359 individuals of African ancestry from the Collaborative Study on the Genetics of Alcoholism to examine the links between polygenic scores (PGSs) for depression, impulsivity/risk-taking, and cognitive performance with 3 self-reported indices of STBs (suicidal ideation, persistent suicidal ideation defined as ideation occurring on at least 7 consecutive days, and suicide attempt) and with NSSI.
Results
UNASSIGNED
The PGS for depression was significantly associated with all 4 primary self-harm measures, explaining 0.6-2.5% of the variance. The PGS for risk-taking behaviors was also associated with all 4 self-harm behaviors in baseline models, but was no longer associated after controlling for a lifetime measure of DSM-IV alcohol dependence and abuse symptom counts. Polygenic predisposition for cognitive performance was negatively associated with suicide attempts (
Conclusions
UNASSIGNED
Our results encourage the study of STB as transdiagnostic outcomes that show genetic overlap with a range of risk factors.
Identifiants
pubmed: 35592092
doi: 10.1159/000517169
pii: cxp-0007-0034
pmc: PMC8443930
doi:
Types de publication
Journal Article
Langues
eng
Pagination
34-44Subventions
Organisme : NIMH NIH HHS
ID : R01 MH123619
Pays : United States
Informations de copyright
Copyright © 2021 by S. Karger AG, Basel.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
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