HDAC Inhibition as Potential Therapeutic Strategy to Restore the Deregulated Immune Response in Severe COVID-19.
COVID-19
Histone deacetylases
T cell exhaustion
cytokines
immune response
inflammation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
13
01
2022
accepted:
01
04
2022
entrez:
20
5
2022
pubmed:
21
5
2022
medline:
24
5
2022
Statut:
epublish
Résumé
The COVID-19 pandemic has had a devastating impact worldwide and has been a great challenge for the scientific community. Vaccines against SARS-CoV-2 are now efficiently lessening COVID-19 mortality, although finding a cure for this infection is still a priority. An unbalanced immune response and the uncontrolled release of proinflammatory cytokines are features of COVID-19 pathophysiology and contribute to disease progression and worsening. Histone deacetylases (HDACs) have gained interest in immunology, as they regulate the innate and adaptative immune response at different levels. Inhibitors of these enzymes have already proven therapeutic potential in cancer and are currently being investigated for the treatment of autoimmune diseases. We thus tested the effects of different HDAC inhibitors, with a focus on a selective HDAC6 inhibitor, on immune and epithelial cells in
Identifiants
pubmed: 35592335
doi: 10.3389/fimmu.2022.841716
pmc: PMC9111747
doi:
Substances chimiques
COVID-19 Vaccines
0
Cytokines
0
Histone Deacetylase Inhibitors
0
Histone Deacetylases
EC 3.5.1.98
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
841716Informations de copyright
Copyright © 2022 Ripamonti, Spadotto, Pozzi, Stevenazzi, Vergani, Marchini, Sandrone, Bonetti, Mazzarella, Minucci, Steinkühler and Fossati.
Déclaration de conflit d'intérêts
CR, VS, PP, AS, BV, MM, GS, GF, and CS are employees of Italfarmaco. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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