Identification of Potential Urinary Metabolite Biomarkers of
Hospital-acquired pneumonia
Pseudomonas aeruginosa
VAP
mass spectrometry
metabolomics
urine biomarkers
Journal
Biomarker insights
ISSN: 1177-2719
Titre abrégé: Biomark Insights
Pays: United States
ID NLM: 101288638
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
10
2021
accepted:
19
04
2022
entrez:
20
5
2022
pubmed:
21
5
2022
medline:
21
5
2022
Statut:
epublish
Résumé
Ventilator-associated pneumonia (VAP) caused by Metabolites were analysed using liquid chromatography-mass spectrometry (LC-MS) in prospectively collected urine samples from mechanically ventilated patients admitted to the Antwerp University Hospital ICU. Patients were followed from the start of mechanical ventilation (n = 100 patients) till the time of clinical diagnosis of VAP (n = 13). Patients (n = 8) in whom diagnosis of VAP was further confirmed by culturing respiratory samples and urine samples were studied for semi-quantitative metabolomics. We first show that multivariate analyses highly discriminated VAP-PA from VAP-non-PA as well as from the pre-infection groups ( Considerable differences exist between urine metabolites in VAP-PA compared to VAP due to other bacterial aetiologies as well to non-VAP (pre-infection) timepoints. The unique urinary metabolic biomarkers we describe here, if further validated, could serve as highly specific diagnostic biomarkers of VAP-PA.
Identifiants
pubmed: 35592849
doi: 10.1177/11772719221099131
pii: 10.1177_11772719221099131
pmc: PMC9112676
doi:
Types de publication
Journal Article
Langues
eng
Pagination
11772719221099131Informations de copyright
© The Author(s) 2022.
Déclaration de conflit d'intérêts
Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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