A scoping review of distributed ledger technology in genomics: thematic analysis and directions for future research.
Blockchain
distributed ledger technology
genomics
literature review
thematic analysis
Journal
Journal of the American Medical Informatics Association : JAMIA
ISSN: 1527-974X
Titre abrégé: J Am Med Inform Assoc
Pays: England
ID NLM: 9430800
Informations de publication
Date de publication:
12 07 2022
12 07 2022
Historique:
received:
28
01
2022
revised:
28
04
2022
accepted:
05
05
2022
pubmed:
21
5
2022
medline:
15
7
2022
entrez:
20
5
2022
Statut:
ppublish
Résumé
Rising interests in distributed ledger technology (DLT) and genomics have sparked various interdisciplinary research streams with a proliferating number of scattered publications investigating the application of DLT in genomics. This review aims to uncover the current state of research on DLT in genomics, in terms of focal research themes and directions for future research. We conducted a scoping review and thematic analysis. To identify the 60 relevant papers, we queried Scopus, Web of Science, PubMed, ACM Digital Library, IEEE Xplore, arXiv, and BiorXiv. Our analysis resulted in 7 focal themes on DLT in genomics discussed in literature, namely: (1) Data economy and sharing; (2) Data management; (3) Data protection; (4) Data storage; (5) Decentralized data analysis; (6) Proof of useful work; and (7) Ethical, legal, and social implications. Based on the identified themes, we present 7 future research directions: (1) Investigate opportunities for the application of DLT concepts other than Blockchain; (2) Explore people's attitudes and behaviors regarding the commodification of genetic data through DLT-based genetic data markets; (3) Examine opportunities for joint consent management via DLT; (4) Investigate and evaluate data storage models appropriate for DLT; (5) Research the regulation-compliant use of DLT in healthcare information systems; (6) Investigate alternative consensus mechanisms based on Proof of Useful Work; and (7) Explore DLT-enabled approaches for the protection of genetic data ensuring user privacy. While research on DLT in genomics is currently growing, there are many unresolved problems. This literature review outlines extant research and provides future directions for researchers and practitioners.
Identifiants
pubmed: 35595301
pii: 6589998
doi: 10.1093/jamia/ocac077
pmc: PMC9277639
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1433-1444Subventions
Organisme : Helmholtz Association
Organisme : Helmholtz Association under the joint research school "HIDSS4Health-Helmholtz Information and Data Science School for Health
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the American Medical Informatics Association.
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