In vitro activity of tedizolid and linezolid against multidrug-resistant Mycobacterium tuberculosis: a comparative study using microdilution broth assay and genomics.

Anti-Bacterial Agents / pharmacology Genomics Humans Linezolid / pharmacology Microbial Sensitivity Tests Mycobacterium tuberculosis Oxazolidinones Tetrazoles Tuberculosis, Multidrug-Resistant / microbiology
Bone marrow suppression Linezolid Minimum inhibitory concentration Multidrug resistance Mycobacterium tuberculosis Tedizolid

Journal

Diagnostic microbiology and infectious disease
ISSN: 1879-0070
Titre abrégé: Diagn Microbiol Infect Dis
Pays: United States
ID NLM: 8305899

Informations de publication

Date de publication:
Jul 2022
Historique:
received: 29 01 2021
revised: 15 03 2022
accepted: 15 04 2022
pubmed: 22 5 2022
medline: 9 6 2022
entrez: 21 5 2022
Statut: ppublish

Résumé

The effects of tedizolid (TZD) against multidrug-resistant Mycobacterium tuberculosis isolates were investigated. This is possibly the first study to evaluate the MIC of TZD against Japanese Mycobacterium tuberculosis isolates. As TZD had a significantly lower MIC than LZD (P < 0.01), it was suggested to be a better, non-toxic alternative to LZD.

Identifiants

DOI: 10.1016/j.diagmicrobio.2022.115714 PMID: 35596983
pubmed: 35596983
pii: S0732-8893(22)00080-3
doi: 10.1016/j.diagmicrobio.2022.115714
pii:
doi:

Substances chimiques

Anti-Bacterial Agents 0
Oxazolidinones 0
Tetrazoles 0
tedizolid 97HLQ82NGL
Linezolid ISQ9I6J12J

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

115714

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare no conflict of interest.

Auteurs

Akio Aono (A)

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan. Electronic address: aono@jata.or.jp.

Yoshiro Murase (Y)

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan.

Kinuyo Chikamatsu (K)

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan.

Yuriko Igarashi (Y)

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan.

Yoshiko Shimomura (Y)

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan.

Makiko Hosoya (M)

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan.

Asami Osugi (A)

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan.

Yuta Morishige (Y)

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan.

Akiko Takaki (A)

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan.

Hiroyuki Yamada (H)

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan.

Satoshi Mitarai (S)

Department of Mycobacterium Reference and Research, The Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association, Kiyose, Japan; Basic Mycobacteriosis, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › In vitro activity of tedizolid and linezolid...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › In vitro activity of tedizolid and linezolid...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › In vitro activity of tedizolid and linezolid...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Oxazoles › Oxazolidinones › Linézolide › In vitro activity of tedizolid and linezolid...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › In vitro activity of tedizolid and linezolid...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Bâtonnets à Gram positif › Bâtonnets asporogènes à Gram positif › Bâtonnets asporogènes réguliers à Gram positif › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis › In vitro activity of tedizolid and linezolid...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Oxazoles › Oxazolidinones › In vitro activity of tedizolid and linezolid...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Tétrazoles › In vitro activity of tedizolid and linezolid...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram positif › Infections à Actinomycetales › Infections à Mycobacterium › Tuberculose › Tuberculose multirésistante › In vitro activity of tedizolid and linezolid...