Combined analysis of cytoarchitectonic, molecular and transcriptomic patterns reveal differences in brain organization across human functional brain systems.
Allen Human Brain Atlas
Julich-Brain atlas
cortical organization
cytoarchitecture
receptor architecture
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
15 08 2022
15 08 2022
Historique:
received:
17
12
2021
revised:
22
03
2022
accepted:
05
05
2022
pubmed:
22
5
2022
medline:
22
6
2022
entrez:
21
5
2022
Statut:
ppublish
Résumé
Brain areas show specific cellular, molecular, and gene expression patterns that are linked to function, but their precise relationships are largely unknown. To unravel these structure-function relationships, a combined analysis of 53 neurotransmitter receptor genes, receptor densities of six transmitter systems and cytoarchitectonic data of the auditory, somatosensory, visual, motor systems was conducted. Besides covariation of areal gene expression with receptor density, the study reveals specific gene expression patterns in functional systems, which are most prominent for the inhibitory GABA
Identifiants
pubmed: 35597401
pii: S1053-8119(22)00407-4
doi: 10.1016/j.neuroimage.2022.119286
pii:
doi:
Substances chimiques
Receptors, Neurotransmitter
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
119286Informations de copyright
Copyright © 2022. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Competing Interest Statement none declared