Heterogeneous SARS-CoV-2 humoral response after COVID-19 vaccination and/or infection in the general population.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
21 05 2022
21 05 2022
Historique:
received:
07
02
2022
accepted:
28
04
2022
entrez:
21
5
2022
pubmed:
22
5
2022
medline:
25
5
2022
Statut:
epublish
Résumé
Assessment of the intensity, dynamics and determinants of the antibody response after SARS-CoV-2 infection or vaccination in the general population is critical to guide vaccination policies. This study characterized the anti-spike IgG titers in 13,971 participants included in a French multicohort population-based serological survey on COVID-19 between April and October 2020 and followed-up with serological testing between May and October 2021. Eight follow-up profiles were defined depending on SARS-CoV-2 infection (0, 1 or 2) and COVID-19 vaccination (0, 1, 2 or 3). The anti-spike titer was lower in adults with no vaccination even in case of infection or reinfection, while it was higher in adults with infection followed by vaccination. The anti-spike titer was negatively correlated with age in vaccinated but uninfected adults, whereas it was positively correlated with age in unvaccinated but infected adults. In adults with 2 vaccine injections and no infection, the vaccine protocol, age, gender, and time since the last vaccine injection were independently associated with the anti-spike titer. The decrease in anti-spike titer was much more rapid in vaccinated than in infected subjects. These results highlight the strong heterogeneity of the antibody response against SARS-CoV-2 in the general population depending on previous infection and vaccination.
Identifiants
pubmed: 35597776
doi: 10.1038/s41598-022-11787-4
pii: 10.1038/s41598-022-11787-4
pmc: PMC9123863
doi:
Substances chimiques
Antibodies, Viral
0
COVID-19 Vaccines
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8622Investigateurs
Fabrice Carrat
(F)
Marie Zins
(M)
Gianluca Severi
(G)
Mathilde Touvier
(M)
Hélène Blanché
(H)
Jean-François Deleuze
(JF)
Xavier de Lamballerie
(X)
Clovis Lusivika-Nzinga
(C)
Gregory Pannetier
(G)
Nathanael Lapidus
(N)
Isabelle Goderel
(I)
Céline Dorival
(C)
Jérôme Nicol
(J)
Olivier Robineau
(O)
Sofiane Kab
(S)
Adeline Renuy
(A)
Stéphane Le-Got
(S)
Céline Ribet
(C)
Mireille Pellicer
(M)
Emmanuel Wiernik
(E)
Marcel Goldberg
(M)
Fanny Artaud
(F)
Pascale Gerbouin-Rérolle
(P)
Mélody Enguix
(M)
Camille Laplanche
(C)
Roselyn Gomes-Rima
(R)
Lyan Hoang
(L)
Emmanuelle Correia
(E)
Alpha Amadou Barry
(AA)
Nadège Senina
(N)
Julien Allegre
(J)
Fabien Szabo de Edelenyi
(FS)
Nathalie Druesne-Pecollo
(N)
Younes Esseddik
(Y)
Serge Hercberg
(S)
Mélanie Deschasaux
(M)
Hélène Blanché
(H)
Jean-Marc Sébaoun
(JM)
Jean-Christophe Beaudoin
(JC)
Laetitia Gressin
(L)
Valérie Morel
(V)
Ouissam Ouili
(O)
Jean-François Deleuze
(JF)
Laetitia Ninove
(L)
Stéphane Priet
(S)
Paola Mariela Saba Villarroel
(PMS)
Toscane Fourié
(T)
Souand Mohamed Ali
(SM)
Abdenour Amroun
(A)
Morgan Seston
(M)
Nazli Ayhan
(N)
Boris Pastorino
(B)
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2022. The Author(s).
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