Feasibility and acceptability of high-intensity interval training and moderate-intensity continuous training in kidney transplant recipients: the PACE-KD study.
Cardiovascular disease
Chronic kidney disease
Feasibility
High-intensity interval training
Kidney transplantation
Journal
Pilot and feasibility studies
ISSN: 2055-5784
Titre abrégé: Pilot Feasibility Stud
Pays: England
ID NLM: 101676536
Informations de publication
Date de publication:
21 May 2022
21 May 2022
Historique:
received:
21
04
2021
accepted:
06
05
2022
entrez:
21
5
2022
pubmed:
22
5
2022
medline:
22
5
2022
Statut:
epublish
Résumé
Kidney transplant recipients (KTRs) exhibit unique elevated inflammation, impaired immune function, and increased cardiovascular risk. Although exercise reduces cardiovascular risk, there is limited research on this population, particularly surrounding novel high-intensity interval training (HIIT). The purpose of this pilot study was to determine the feasibility and acceptability of HIIT in KTRs. Twenty KTRs (male 14; eGFR 58±19 mL/min/1.73 m Twenty participants completed the intervention, and 8 of whom achieved the required intensity based on power output (HIIT A, 0/6 [0%]; HIITB, 3/8 [38%]; MICT, 5/6 [83%]). Participants completed 92% of the 24 sessions with 105 cancelled and rescheduled sessions and an average of 10 weeks to complete the intervention. Pre-intervention versus post-intervention V̇O This is the first study to report the feasibility of HIIT in KTRs. Although participants struggled to achieve the required intensity (power), this study highlights the potential that exercise has to reduce cardiovascular risk in KTRs. HIIT and MICT performed on a cycle, with some modification, could be considered safe and feasible in KTRs. Larger scale trials are required to assess the efficacy of HIIT in KTRs and in particular identify the most appropriate intensities, recovery periods, and session duration. Some flexibility in delivery, such as incorporating home-based sessions, may need to be considered to improve recruitment and retention. ISRCTN, ISRCTN17122775 . Registered on 30 January 2017.
Sections du résumé
BACKGROUND
BACKGROUND
Kidney transplant recipients (KTRs) exhibit unique elevated inflammation, impaired immune function, and increased cardiovascular risk. Although exercise reduces cardiovascular risk, there is limited research on this population, particularly surrounding novel high-intensity interval training (HIIT). The purpose of this pilot study was to determine the feasibility and acceptability of HIIT in KTRs.
METHODS
METHODS
Twenty KTRs (male 14; eGFR 58±19 mL/min/1.73 m
RESULTS
RESULTS
Twenty participants completed the intervention, and 8 of whom achieved the required intensity based on power output (HIIT A, 0/6 [0%]; HIITB, 3/8 [38%]; MICT, 5/6 [83%]). Participants completed 92% of the 24 sessions with 105 cancelled and rescheduled sessions and an average of 10 weeks to complete the intervention. Pre-intervention versus post-intervention V̇O
CONCLUSIONS
CONCLUSIONS
This is the first study to report the feasibility of HIIT in KTRs. Although participants struggled to achieve the required intensity (power), this study highlights the potential that exercise has to reduce cardiovascular risk in KTRs. HIIT and MICT performed on a cycle, with some modification, could be considered safe and feasible in KTRs. Larger scale trials are required to assess the efficacy of HIIT in KTRs and in particular identify the most appropriate intensities, recovery periods, and session duration. Some flexibility in delivery, such as incorporating home-based sessions, may need to be considered to improve recruitment and retention.
TRIAL REGISTRATION
BACKGROUND
ISRCTN, ISRCTN17122775 . Registered on 30 January 2017.
Identifiants
pubmed: 35597974
doi: 10.1186/s40814-022-01067-3
pii: 10.1186/s40814-022-01067-3
pmc: PMC9123685
doi:
Types de publication
Journal Article
Langues
eng
Pagination
106Subventions
Organisme : Heart Research UK
ID : RG2650/15/18
Informations de copyright
© 2022. The Author(s).
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