TRPC6 is altered in COVID-19 pneumonia.
COVID pneumonia
Human lung
Immunohistochemistry
TRPC6 channels
Therapy
Journal
Chemico-biological interactions
ISSN: 1872-7786
Titre abrégé: Chem Biol Interact
Pays: Ireland
ID NLM: 0227276
Informations de publication
Date de publication:
01 Aug 2022
01 Aug 2022
Historique:
received:
22
03
2022
revised:
25
04
2022
accepted:
09
05
2022
pubmed:
23
5
2022
medline:
18
6
2022
entrez:
22
5
2022
Statut:
ppublish
Résumé
In this Letter to the Editor supportive data were presented to a recent paper published in this journal reporting the involvement of TRP channels in COVID-19 pneumonia and its role for new therapies. Since gene expression of TRP channels was found in human lung tissues the protein was not being reported so far. TRP channels are supposed to be involved in the pulmonary inflammation and its symptoms such as fever, cough and others. Here, TRPC6 was investigated in tissues of normal human lungs and of SARS-Cov-2 infected lungs in a preliminary study. Tissue was obtained post mortem from anatomical body donations during dissections and during pathological dissections (13 normal, 4 COVID-19 pneumoniae) and processed for immunohistochemistry. In normal lungs TRPC6 was found in the ciliated epithelium, in the wall of larger lung vessels and in the alveolar septa. In COVID-19 pneumonia the distribution of TRPC6 was different. Inflammatory lesions, cellular infiltrates, hyaline membranes and fibrosis were labelled intensively as well as dilated capillaries. These observations are from four patients with COVID-19 pneumonia.The observations do not elucidate the molecular mechanisms but support the view that TRPC6 channels are involved in normal physiology of normal human lungs and in COVID-19 pneumonia. TRPC6 might aggravate SARS-2 induced inflammation and could be a target for inhibiting drugs.
Identifiants
pubmed: 35598647
pii: S0009-2797(22)00187-9
doi: 10.1016/j.cbi.2022.109982
pmc: PMC9119708
pii:
doi:
Substances chimiques
TRPC6 Cation Channel
0
TRPC6 protein, human
0
Types de publication
Letter
Langues
eng
Sous-ensembles de citation
IM
Pagination
109982Informations de copyright
Copyright © 2022 Elsevier B.V. All rights reserved.
Références
ACS Omega. 2021 Mar 24;6(13):9196-9203
pubmed: 33842788
J Diabetes Res. 2020 Sep 16;2020:3634974
pubmed: 33015191
Pharmaceuticals (Basel). 2019 Feb 01;12(1):
pubmed: 30717260
Am J Respir Cell Mol Biol. 2010 Sep;43(3):296-304
pubmed: 19843708
Cell Calcium. 2017 Nov;67:123-137
pubmed: 28499580
Rev Physiol Biochem Pharmacol. 2013;165:31-65
pubmed: 23532495
Drug Des Devel Ther. 2020 Jan 28;14:361-370
pubmed: 32095070
Biomed Rep. 2022 May;16(5):42
pubmed: 35371476
Brain Res Mol Brain Res. 2002 Dec 30;109(1-2):95-104
pubmed: 12531519
Chem Biol Interact. 2021 Aug 25;345:109567
pubmed: 34166652
Biomedicines. 2021 Sep 30;9(10):
pubmed: 34680477