In vitro antiproliferative and cytotoxic activities of novel triphenyltin isoselenocyanate in human breast carcinoma cell lines MCF 7 and MDA-MB-231.
Apoptosis
Breast cancer
Cytotoxicity
DNA crosslinks
Migration
Triorganotin isoselenocyanates
Journal
Medical oncology (Northwood, London, England)
ISSN: 1559-131X
Titre abrégé: Med Oncol
Pays: United States
ID NLM: 9435512
Informations de publication
Date de publication:
23 May 2022
23 May 2022
Historique:
received:
22
12
2021
accepted:
21
02
2022
entrez:
22
5
2022
pubmed:
23
5
2022
medline:
25
5
2022
Statut:
epublish
Résumé
Intensive investigation for novel antiproliferative and cytotoxic effective chemical compounds is currently concentrated on structurally modified agents of natural or synthetic source. The selenium derivative of triorganotin compound, triphenyltin isoselenocyanate (TPT-NCSe) caused higher cytotoxicity in hormone sensitive MCF 7 (IC 50-250 nM) in comparison with triple-negative MDA-MB-231 breast carcinoma cell line (IC 50-450 nM) as determined by MTT assay. Measurement of DNA damage showed presence of crosslinks in both cell lines treated by increasing TPT-NCSe concentrations. This compound decreased mitochondrial membrane potential shown by JC-1 staining in a concentration-dependent manner in both cell lines. Activation of caspases-3/7 was observed in MDA-MB-231 cells and was significant only by concentrations causing significant level of crosslinks. On the other hand, migration assay revealed inhibitory effect of viability keeping 100 nM concentration of TPT-NCSe on migration of MDA-MB-231 cells. Our data has shown that this selenium containing triorganotin molecule exerts DNA damage-linked antineoplastic activity in breast carcinoma cell lines studied.
Identifiants
pubmed: 35599282
doi: 10.1007/s12032-022-01692-1
pii: 10.1007/s12032-022-01692-1
doi:
Substances chimiques
Antineoplastic Agents
0
Organoselenium Compounds
0
Organotin Compounds
0
isoselenocyanate
0
triphenyltin
95T92AGN0V
Selenium
H6241UJ22B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
99Subventions
Organisme : Agentúra na Podporu Výskumu a Vývoja
ID : APVV-15-0372
Organisme : Agentúra na Podporu Výskumu a Vývoja
ID : APVV-20-0314
Organisme : Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
ID : VEGA 2/0126/19
Organisme : Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
ID : VEGA 1/0460/21
Organisme : Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
ID : VEGA 1/0136/18
Organisme : Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
ID : VEGA 1/0489/20
Organisme : Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
ID : VEGA 2/0116/21
Organisme : Masarykova Univerzita
ID : MUNI/A/1682/2020
Organisme : ERDF
ID : TRANSMED 2, ITMS: 26240120030
Organisme : ERDF
ID : TRANSMED, ITMS: 26240120008
Organisme : ERDF
ID : ITMS: 26240220071
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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