The pharmacological and pharmacokinetic properties of esculin: A comprehensive review.
esculin
natural products
pharmacokinetics
pharmacological effects
Journal
Phytotherapy research : PTR
ISSN: 1099-1573
Titre abrégé: Phytother Res
Pays: England
ID NLM: 8904486
Informations de publication
Date de publication:
Jun 2022
Jun 2022
Historique:
revised:
25
03
2022
received:
31
12
2021
accepted:
06
04
2022
pubmed:
24
5
2022
medline:
22
6
2022
entrez:
23
5
2022
Statut:
ppublish
Résumé
Cortex fraxini is a widely used traditional Chinese medicine. Esculin is one of the main active ingredients of Cortex fraxini and has attracted more and more attention from scholars. The purpose of the review is to systematically review relevant studies on the pharmacological effects and pharmacokinetic characteristics of esculin to support its further application as therapeutic agents. Pharmacological studies have shown that the anti-inflammatory and anti-oxidative stress effects of esculin are outstanding. This indicates that esculin is promising to be used to treat a variety of diseases closely related to inflammation and oxidative damage. Esculin has anti-diabetic effect, which is closely related to improving pancreas damage, promoting insulin release, and enhancing glucose homeostasis. In addition, esculin has anti-cancer, antibiosis, anti-virus, neuroprotection, anti-thrombosis and treating eye diseases properties. Pharmacokinetic studies show that esculin can be quickly and evenly distributed in the body. However, the first pass effect of esculin is serious. In short, esculin is promising to treat many diseases, but further high quality studies are needed to firmly establish the clinical efficacy of esculin.
Substances chimiques
Anti-Inflammatory Agents
0
Insulin
0
Esculin
1Y1L18LQAF
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2434-2448Subventions
Organisme : Sichuan Provincial Administration of Traditional Chinese Medicine
ID : 2018QN019
Informations de copyright
© 2022 John Wiley & Sons Ltd.
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