The genetic architecture of Alzheimer disease risk in the Ohio and Indiana Amish.
Alzheimer disease
Amish
GRS
PRS
SNP
founder population
genetic architecture
genetic risk score
polygenic risk score
prediction
Journal
HGG advances
ISSN: 2666-2477
Titre abrégé: HGG Adv
Pays: United States
ID NLM: 101772885
Informations de publication
Date de publication:
14 Jul 2022
14 Jul 2022
Historique:
received:
20
12
2021
accepted:
22
04
2022
entrez:
23
5
2022
pubmed:
24
5
2022
medline:
24
5
2022
Statut:
epublish
Résumé
Alzheimer disease (AD) is the most common type of dementia and is currently estimated to affect 6.2 million Americans. It ranks as the sixth leading cause of death in the United States, and the proportion of deaths due to AD has been increasing since 2000, while the proportion of many other leading causes of deaths have decreased or remained constant. The risk for AD is multifactorial, including genetic and environmental risk factors. Although
Identifiants
pubmed: 35599847
doi: 10.1016/j.xhgg.2022.100114
pii: S2666-2477(22)00030-6
pmc: PMC9114685
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100114Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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