Exercise Capacity in Children and Adolescents With Congenital Heart Disease: A Systematic Review and Meta-Analysis.
cardiopulmonary exercise test
congenital malformations
heart defects
oxygen consumption
pediatrics
six-minute walking test
Journal
Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388
Informations de publication
Date de publication:
2022
2022
Historique:
received:
12
02
2022
accepted:
29
03
2022
entrez:
23
5
2022
pubmed:
24
5
2022
medline:
24
5
2022
Statut:
epublish
Résumé
Congenital heart disease (CHD) entails structural defects in the morphogenesis of the heart or its main vessels. Analyzing exercise capacity of children and adolescents with CHD is important to improve their functional condition and quality of life, since it can allow timely intervention on poor prognostic factors associated with higher risk of morbidity and mortality. To describe exercise capacity in children and adolescents with CHD compared with healthy controls. A systematic review was carried out. Randomized clinical trials and observational studies were included assessing exercise capacity through direct and indirect methods in children and adolescents between 5 and 17 years-old. A sensitive analysis was performed including studies with CHD repaired participants. Additionally, it was sub-analyzed by age range (< and ≥ 12 years old). Two independent reviewers analyzed the studies, extracted the data, and assessed the quality of the evidence. 5619 articles were found and 21 were considered for the review. Eighteen articles used the direct exercise capacity measurement method by cardiopulmonary exercise test (CPET). The CHD group showed significant differences in peak oxygen consumption (VO Suffering CHD in childhood and adolescence is associated with lower exercise capacity as shown by worse VO www.crd.york.ac.uk/prospero/display_record.php?RecordID=208963, identifier: CRD42020208963.
Sections du résumé
Background
UNASSIGNED
Congenital heart disease (CHD) entails structural defects in the morphogenesis of the heart or its main vessels. Analyzing exercise capacity of children and adolescents with CHD is important to improve their functional condition and quality of life, since it can allow timely intervention on poor prognostic factors associated with higher risk of morbidity and mortality.
Objective
UNASSIGNED
To describe exercise capacity in children and adolescents with CHD compared with healthy controls.
Methods
UNASSIGNED
A systematic review was carried out. Randomized clinical trials and observational studies were included assessing exercise capacity through direct and indirect methods in children and adolescents between 5 and 17 years-old. A sensitive analysis was performed including studies with CHD repaired participants. Additionally, it was sub-analyzed by age range (< and ≥ 12 years old). Two independent reviewers analyzed the studies, extracted the data, and assessed the quality of the evidence.
Results
UNASSIGNED
5619 articles were found and 21 were considered for the review. Eighteen articles used the direct exercise capacity measurement method by cardiopulmonary exercise test (CPET). The CHD group showed significant differences in peak oxygen consumption (VO
Conclusion
UNASSIGNED
Suffering CHD in childhood and adolescence is associated with lower exercise capacity as shown by worse VO
Systematic Review Registration
UNASSIGNED
www.crd.york.ac.uk/prospero/display_record.php?RecordID=208963, identifier: CRD42020208963.
Identifiants
pubmed: 35600470
doi: 10.3389/fcvm.2022.874700
pmc: PMC9114479
doi:
Types de publication
Systematic Review
Langues
eng
Pagination
874700Informations de copyright
Copyright © 2022 Villaseca-Rojas, Varela-Melo, Torres-Castro, Vasconcello-Castillo, Mazzucco, Vilaró and Blanco.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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