Neuronal Dysfunction Is Linked to the Famine-Associated Risk of Proliferative Retinopathy in Patients With Type 2 Diabetes.
diabetic retinopathy
famine
intrauterine exposure
neurodegeneration
neuronal function
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2022
2022
Historique:
received:
19
01
2022
accepted:
28
03
2022
entrez:
23
5
2022
pubmed:
24
5
2022
medline:
24
5
2022
Statut:
epublish
Résumé
Persons with type 2 diabetes born in the regions of famine exposures have disproportionally elevated risk of vision-threatening proliferative diabetic retinopathy (PDR) in adulthood. However, the underlying mechanisms are not known. In the present study, we aimed to investigate the plausible molecular factors underlying progression to PDR. To study the association of genetic variants with PDR under the intrauterine famine exposure, we analyzed single nucleotide polymorphisms (SNPs) that were previously reported to be associated with type 2 diabetes, glucose, and pharmacogenetics. Analyses were performed in the population from northern Ukraine with a history of exposure to the Great Ukrainian Holodomor famine [the Diagnostic Optimization and Treatment of Diabetes and its Complications in the Chernihiv Region (DOLCE study),
Identifiants
pubmed: 35600617
doi: 10.3389/fnins.2022.858049
pmc: PMC9119187
doi:
Types de publication
Journal Article
Langues
eng
Pagination
858049Informations de copyright
Copyright © 2022 Fedotkina, Jain, Prasad, Luk, García-Ramírez, Özgümüs, Cherviakova, Khalimon, Svietleisha, Buldenko, Kravchenko, Jain, Vaag, Chan, Khalangot, Hernández, Nilsson, Simo, Artner and Lyssenko.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Microcirculation. 2010 Nov;17(8):660-8
pubmed: 21044220
Biostatistics. 2007 Jan;8(1):118-27
pubmed: 16632515
Cell Death Dis. 2016 Dec 8;7(12):e2514
pubmed: 27929541
Diabetes. 2019 Feb;68(2):457-463
pubmed: 30389750
Diabetologia. 2018 Sep;61(9):1902-1912
pubmed: 30030554
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
Genomics. 2011 Oct;98(4):288-95
pubmed: 21839163
Front Genet. 2021 Jul 02;12:637945
pubmed: 34276762
Lancet Diabetes Endocrinol. 2018 May;6(5):361-369
pubmed: 29503172
Diabetes Care. 1998 Dec;21(12):2191-2
pubmed: 9839117
Dev Biol. 2008 Aug 1;320(1):242-55
pubmed: 18582859
Epidemiology. 1998 Nov;9(6):618-21
pubmed: 9799170
Bioinformatics. 2013 Jan 15;29(2):189-96
pubmed: 23175756
Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13924-9
pubmed: 25201977
PLoS Biol. 2004 Sep;2(9):E247
pubmed: 15226823
Diabetes Metab Res Rev. 2017 Nov;33(8):
pubmed: 28731281
Front Cell Dev Biol. 2021 Nov 18;9:726852
pubmed: 34869314
N Engl J Med. 2008 Jul 3;359(1):61-73
pubmed: 18596274
Diabetes Care. 2014 Apr;37(4):893-9
pubmed: 24652720
PLoS One. 2014 Jun 12;9(6):e98736
pubmed: 24922313
PLoS One. 2009 Dec 18;4(12):e8274
pubmed: 20019873
PLoS Biol. 2010 Jun 29;8(6):e1000412
pubmed: 20613859
PLoS Med. 2007 May;4(5):e158
pubmed: 17472435
Nat Genet. 2003 May;34(1):53-8
pubmed: 12692551
Curr Environ Health Rep. 2015 Jun;2(2):145-54
pubmed: 26231364
Pediatr Res. 2002 Jun;51(6):675-80
pubmed: 12032260
Dev Cell. 2017 Dec 18;43(6):763-779.e4
pubmed: 29233477
Oncotarget. 2017 Jan 17;8(3):5629-5637
pubmed: 27895318
BMC Bioinformatics. 2010 Nov 30;11:587
pubmed: 21118553
Mol Cell Endocrinol. 2001 Dec 20;185(1-2):93-8
pubmed: 11738798
Diab Vasc Dis Res. 2007 Sep;4 Suppl 3:S9-S11
pubmed: 17935059
Bioinformatics. 2011 Sep 1;27(17):2453-4
pubmed: 21727141
Acta Ophthalmol. 2022 Mar;100(2):e539-e545
pubmed: 34169655
Int J Neurosci. 2016 Aug;126(8):675-80
pubmed: 26040332
Diabetes. 2016 Jan;65(1):172-87
pubmed: 26384381
Paediatr Perinat Epidemiol. 2001 Jan;15(1):74-87
pubmed: 11237119
Lancet Diabetes Endocrinol. 2015 Oct;3(10):787-94
pubmed: 26342852
Mol Psychiatry. 2018 Sep;23(9):1900-1910
pubmed: 28848234
Am J Hum Genet. 2007 Sep;81(3):559-75
pubmed: 17701901
Curr Eye Res. 2019 Jan;44(1):34-45
pubmed: 30198788
Sci Adv. 2018 Jan 31;4(1):eaao4364
pubmed: 29399631
Circulation. 2008 Jul 29;118(5):518-24
pubmed: 18625895
Diabetes Care. 2006 Aug;29(8):1897-901
pubmed: 16873799
Ann N Y Acad Sci. 2014 Apr;1311:174-90
pubmed: 24673341
Psychoneuroendocrinology. 2014 Jun;44:112-22
pubmed: 24767625
Science. 2015 May 8;348(6235):648-60
pubmed: 25954001
Nat Rev Dis Primers. 2016 Mar 17;2:16012
pubmed: 27159554
N Engl J Med. 1994 Dec 1;331(22):1480-7
pubmed: 7526212
Bioinformatics. 2008 Jul 1;24(13):1547-8
pubmed: 18467348
Trends Endocrinol Metab. 2014 Jan;25(1):23-33
pubmed: 24183659
Diabetes. 2018 Jul;67(7):1414-1427
pubmed: 29703844
Lancet Glob Health. 2017 Dec;5(12):e1221-e1234
pubmed: 29032195