The Role of Geranylgeraniol in Managing Bisphosphonate-Related Osteonecrosis of the Jaw.
angiogenesis
bone
gingival fibroblast
osteoblasts
osteoclasts
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
02
2022
accepted:
20
04
2022
entrez:
23
5
2022
pubmed:
24
5
2022
medline:
24
5
2022
Statut:
epublish
Résumé
Medication-related osteonecrosis of the jaw (ONJ) is a rare but significant adverse side effect of antiresorptive drugs. Bisphosphonate-related ONJ (BRONJ) is the most prevalent condition due to the extensive use of the drug in cancer and osteoporosis treatment. Nitrogen-containing bisphosphonates suppress osteoclastic resorption by inhibiting farnesyl pyrophosphate synthase in the mevalonate pathway, leading to deficiency of the substrate for GTPase prenylation. The bone remodelling process is uncoupled, subsequently impairing bone healing and causing ONJ. Targeted administration of geranylgeraniol (GGOH) represents a promising approach to mitigate BRONJ because GGOH is a substrate for GTPase prenylation. In the current review, the
Identifiants
pubmed: 35600875
doi: 10.3389/fphar.2022.878556
pii: 878556
pmc: PMC9114760
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
878556Informations de copyright
Copyright © 2022 Chin, Ekeuku and Trias.
Déclaration de conflit d'intérêts
Author AT was employed by American River Nutrition. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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