Endothelial NOX4 Oxidase Negatively Regulates Inflammation and Improves Morbidity During Influenza A Virus Lung Infection in Mice.
Animals
Endothelium
/ metabolism
Inflammation
/ metabolism
Influenza A Virus, H3N2 Subtype
Lung
/ pathology
Mice
Mice, Inbred C57BL
Mice, Transgenic
Morbidity
NADPH Oxidase 4
/ metabolism
Orthomyxoviridae Infections
/ pathology
Oxidoreductases
/ metabolism
Pneumonia
/ pathology
Reactive Oxygen Species
/ metabolism
NADPH oxidase 4(NOX4)
endothelial cell
inflammation
influenza A virus
oxidative stress
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2022
2022
Historique:
received:
25
02
2022
accepted:
07
04
2022
entrez:
23
5
2022
pubmed:
24
5
2022
medline:
25
5
2022
Statut:
epublish
Résumé
Endosomal NOX2 oxidase-dependent ROS production promotes influenza pathogenicity, but the role of NOX4 oxidase, which is highly expressed in the lung endothelium, is largely unknown. The aim of this study was to determine if endothelial NOX4 expression can influence viral pathology
Identifiants
pubmed: 35601109
doi: 10.3389/fcimb.2022.883448
pmc: PMC9115386
doi:
Substances chimiques
Reactive Oxygen Species
0
Oxidoreductases
EC 1.-
NADPH Oxidase 4
EC 1.6.3.-
Nox4 protein, mouse
EC 1.6.3.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
883448Informations de copyright
Copyright © 2022 Hendricks, To, Luong, Liong, Erlich, Shah, Liong, O’Leary, Brooks, Vlahos and Selemidis.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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