Poly(pseudo)rotaxanes formed by mixed micelles and α-cyclodextrin enhance terbinafine nail permeation to deeper layers.
CDs, cyclodextrins
GEL, Gelucire® 48/16
Mixed micelles
Nail permeation
Onychomycosis
PEG, polyethylene glycol
PPR, poly(pseudo)rotaxane
PdI, polydispersity index
Poly(pseudo)rotaxanes
RH40, Kolliphor® RH40
RH40:GEL, mixture of RH40 and GEL 1:1
Supramolecular gels
TB, terbinafine hydrochloride
Terbinafine
Journal
International journal of pharmaceutics: X
ISSN: 2590-1567
Titre abrégé: Int J Pharm X
Pays: Netherlands
ID NLM: 101753452
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
05
05
2022
accepted:
07
05
2022
entrez:
23
5
2022
pubmed:
24
5
2022
medline:
24
5
2022
Statut:
epublish
Résumé
This work aimed to develop water-based formulations for onychomycosis topical treatment using micelles of small pegylated surfactants associated with α-cyclodextrin (αCD) to deliver terbinafine to the nail. Kolliphor® RH40 (RH40) and Gelucire® 48/16 (GEL) single and mixed micelles (RH40:GEL 1:1) were prepared. αCD was added to the surfactants dispersions to form poly(pseudo)rotaxanes (PPR). Formulations were characterized in terms of drug solubilization (3 to 34-fold increase), particle size (9-11 nm) and
Identifiants
pubmed: 35602759
doi: 10.1016/j.ijpx.2022.100118
pii: S2590-1567(22)00007-X
pmc: PMC9117884
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100118Informations de copyright
© 2022 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
Int J Pharm. 2017 Oct 5;531(1):292-298
pubmed: 28859937
Eur J Pharm Sci. 2018 May 30;117:270-278
pubmed: 29501459
J Pharm Sci. 2006 Jun;95(6):1173-6
pubmed: 16639718
Materials (Basel). 2018 Apr 27;11(5):
pubmed: 29702593
Eur J Pharm Sci. 2018 Oct 15;123:217-227
pubmed: 30048800
Int J Pharm. 2010 Jun 30;393(1-2):112-8
pubmed: 20412843
Drug Deliv Transl Res. 2016 Jun;6(3):263-75
pubmed: 26926242
J Pharm Sci. 2007 Dec;96(12):3352-62
pubmed: 17786922
Mycoses. 2009 Jan;52(1):35-43
pubmed: 18498299
Int J Pharm. 2002 Apr 2;236(1-2):1-26
pubmed: 11891066
J Hand Surg Am. 2014 May;39(5):985-8
pubmed: 24766830
Antimicrob Agents Chemother. 2014 Jun;58(6):3553-5
pubmed: 24709260
Chem Asian J. 2014 May;9(5):1365-72
pubmed: 24665042
J Control Release. 2011 Dec 20;156(3):337-44
pubmed: 21906642
J Control Release. 2014 Apr 28;180:60-70
pubmed: 24560884
Crit Rev Ther Drug Carrier Syst. 2019;36(1):1-58
pubmed: 30806205
AAPS PharmSciTech. 2017 Aug;18(6):2316-2328
pubmed: 28116600
AAPS PharmSciTech. 2017 Feb;18(2):551-562
pubmed: 27138036
Mycoses. 2019 Jun;62(6):494-501
pubmed: 30667544
PLoS One. 2016 Jul 21;11(7):e0159661
pubmed: 27441843
Eur J Pharm Sci. 2006 Oct 1;29(2):111-9
pubmed: 16870405
Curr Drug Deliv. 2010 Dec;7(5):407-14
pubmed: 20955143
Eur J Pharm Biopharm. 2013 Apr;83(3):370-7
pubmed: 23201053
Int J Pharm. 2010 Feb 15;386(1-2):185-94
pubmed: 19941943
AAPS PharmSciTech. 2011 Jun;12(2):496-506
pubmed: 21479748
Pharmaceutics. 2018 Dec 13;10(4):
pubmed: 30551601
Int J Pharm. 2002 Oct 1;245(1-2):25-36
pubmed: 12270239
AAPS J. 2021 Jan 13;23(1):25
pubmed: 33439400
Chem Commun (Camb). 2015 Apr 14;51(29):6275-89
pubmed: 25679097
Eur J Pharm Sci. 2016 Jun 10;88:91-100
pubmed: 27072432
Int J Pharm. 2009 Jun 22;375(1-2):22-7
pubmed: 19481686
Eur J Pharm Sci. 2017 Nov 15;109:288-296
pubmed: 28823856
Nanomaterials (Basel). 2019 May 15;9(5):
pubmed: 31096569
J Pharm Sci. 2016 Mar;105(3):1201-8
pubmed: 26886342
J Pharm Sci. 2009 May;98(5):1788-96
pubmed: 18781625
Int J Pharm. 2016 Mar 16;500(1-2):11-9
pubmed: 26795192
Int J Pharm. 2021 Jun 1;602:120597
pubmed: 33862134
Curr Pharm Des. 2017 Nov 14;:
pubmed: 29141535
AAPS PharmSciTech. 2014 Dec;15(6):1429-38
pubmed: 24970585
J Pharm Sci. 2017 Jun;106(6):1570-1577
pubmed: 28263845
Carbohydr Polym. 2018 Nov 15;200:278-288
pubmed: 30177168
J Pharm Sci. 2010 Oct;99(10):4267-76
pubmed: 20737634
Pharmaceutics. 2018 Sep 11;10(3):
pubmed: 30208659
Am J Clin Dermatol. 2003;4(1):39-65
pubmed: 12477372
J Drug Deliv. 2014;2014:950358
pubmed: 25177500
J Liposome Res. 2016;26(2):163-73
pubmed: 26226352
AAPS PharmSciTech. 2019 Jun 6;20(5):215
pubmed: 31172376
Int J Pharm. 2012 Oct 15;436(1-2):179-82
pubmed: 22705091
J Control Release. 2015 Feb 10;199:132-44
pubmed: 25481439
J Pharm Sci. 2009 Nov;98(11):4130-40
pubmed: 19340887
Int J Pharm. 2010 Sep 15;397(1-2):67-76
pubmed: 20620203
Int J Pharm. 2020 Aug 30;586:119510
pubmed: 32531449
Ther Deliv. 2018 Feb;9(2):99-119
pubmed: 29325509