Development and preliminary validation of infrared spectroscopic device for transdermal assessment of elevated cardiac troponin.
Cardiac device therapy
Infrared spectroscopy
Journal
Communications medicine
ISSN: 2730-664X
Titre abrégé: Commun Med (Lond)
Pays: England
ID NLM: 9918250414506676
Informations de publication
Date de publication:
2022
2022
Historique:
received:
04
03
2021
accepted:
18
03
2022
entrez:
23
5
2022
pubmed:
24
5
2022
medline:
24
5
2022
Statut:
epublish
Résumé
The levels of circulating troponin are principally required in addition to electrocardiograms for the effective diagnosis of acute coronary syndrome. Current standard-of-care troponin assays provide a snapshot or momentary view of the levels due to the requirement of a blood draw. This modality further restricts the number of measurements given the clinical context of the patient. In this communication, we present the development and early validation of non-invasive transdermal monitoring of cardiac troponin-I to detect its elevated state. Our device relies on infrared spectroscopic detection of troponin-I through the dermis and is tested in stepwise laboratory, benchtop, and clinical studies. Patients were recruited with suspected acute coronary syndrome. We demonstrate a significant correlation ( This preliminary work introduces the potential of a bloodless transdermal measurement of troponin-I based on molecular spectroscopy. Further, potential pitfalls associated with infrared spectroscopic mode of inquiry are outlined including requisite steps needed for improving the precision and overall diagnostic value of the device in future studies.
Sections du résumé
Background
UNASSIGNED
The levels of circulating troponin are principally required in addition to electrocardiograms for the effective diagnosis of acute coronary syndrome. Current standard-of-care troponin assays provide a snapshot or momentary view of the levels due to the requirement of a blood draw. This modality further restricts the number of measurements given the clinical context of the patient. In this communication, we present the development and early validation of non-invasive transdermal monitoring of cardiac troponin-I to detect its elevated state.
Methods
UNASSIGNED
Our device relies on infrared spectroscopic detection of troponin-I through the dermis and is tested in stepwise laboratory, benchtop, and clinical studies. Patients were recruited with suspected acute coronary syndrome.
Results
UNASSIGNED
We demonstrate a significant correlation (
Conclusion
UNASSIGNED
This preliminary work introduces the potential of a bloodless transdermal measurement of troponin-I based on molecular spectroscopy. Further, potential pitfalls associated with infrared spectroscopic mode of inquiry are outlined including requisite steps needed for improving the precision and overall diagnostic value of the device in future studies.
Identifiants
pubmed: 35603300
doi: 10.1038/s43856-022-00104-9
pii: 104
pmc: PMC9053220
doi:
Types de publication
Journal Article
Langues
eng
Pagination
42Informations de copyright
© The Author(s) 2022.
Déclaration de conflit d'intérêts
Competing interestsP.S. is an advisor to Kencor Health, Ultromics and RCE Technologies and holds option equity with these companies. A.W. is an advisor and holds option equity with RCE Technologies. S.B. holds option equity with RCE Technologies. J.T. and A.B. are employees of RCE Technologies.
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