From Antarctica to cancer research: a novel human DNA topoisomerase 1B inhibitor from Antarctic sponge


Journal

Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203

Informations de publication

Date de publication:
Dec 2022
Historique:
entrez: 23 5 2022
pubmed: 24 5 2022
medline: 25 5 2022
Statut: ppublish

Résumé

Nature has been always a great source of possible lead compounds to develop new drugs against several diseases. Here we report the identification of a natural compound, membranoid G, derived from the Antarctic sponge

Identifiants

pubmed: 35603503
doi: 10.1080/14756366.2022.2078320
pmc: PMC9132426
doi:

Substances chimiques

Antineoplastic Agents 0
Topoisomerase Inhibitors 0
DNA 9007-49-2
DNA Topoisomerases, Type I EC 5.99.1.2
DNA Topoisomerases, Type II EC 5.99.1.3

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1404-1410

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Auteurs

Alessio Ottaviani (A)

Department of Biology, University of Rome Tor Vergata, Rome, Italy.

Joshua Welsch (J)

Department of Chemistry, University of South Florida, Tampa, FL, USA.

Keli Agama (K)

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Yves Pommier (Y)

Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.

Alessandro Desideri (A)

Department of Biology, University of Rome Tor Vergata, Rome, Italy.

Bill J Baker (BJ)

Department of Chemistry, University of South Florida, Tampa, FL, USA.

Paola Fiorani (P)

Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Institute of Translational Pharmacology, National Research Council, CNR, Rome, Italy.

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Classifications MeSH