Lung Cancer and Radon: Pooled Analysis of Uranium Miners Hired in 1960 or Later.
Journal
Environmental health perspectives
ISSN: 1552-9924
Titre abrégé: Environ Health Perspect
Pays: United States
ID NLM: 0330411
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
entrez:
23
5
2022
pubmed:
24
5
2022
medline:
26
5
2022
Statut:
ppublish
Résumé
Despite reductions in exposure for workers and the general public, radon remains a leading cause of lung cancer. Prior studies of underground miners depended heavily upon information on deaths among miners employed in the early years of mine operations when exposures were high and tended to be poorly estimated. To strengthen the basis for radiation protection, we report on the follow-up of workers employed in the later periods of mine operations for whom we have more accurate exposure information and for whom exposures tended to be accrued at intensities that are more comparable to contemporary settings. We conducted a pooled analysis of cohort studies of lung cancer mortality among 57,873 male uranium miners in Canada, Czech Republic, France, Germany, and the United States, who were first employed in 1960 or later (thereby excluding miners employed during the periods of highest exposure and focusing on miners who tend to have higher quality assessments of radon progeny exposures). We derived estimates of excess relative rate per 100 working level months (ERR/100 WLM) for mortality from lung cancer. The analysis included Estimates of association between radon progeny exposure and lung cancer mortality among relatively contemporary miners are coherent with estimates used to inform current protection guidelines. https://doi.org/10.1289/EHP10669.
Sections du résumé
BACKGROUND
Despite reductions in exposure for workers and the general public, radon remains a leading cause of lung cancer. Prior studies of underground miners depended heavily upon information on deaths among miners employed in the early years of mine operations when exposures were high and tended to be poorly estimated.
OBJECTIVES
To strengthen the basis for radiation protection, we report on the follow-up of workers employed in the later periods of mine operations for whom we have more accurate exposure information and for whom exposures tended to be accrued at intensities that are more comparable to contemporary settings.
METHODS
We conducted a pooled analysis of cohort studies of lung cancer mortality among 57,873 male uranium miners in Canada, Czech Republic, France, Germany, and the United States, who were first employed in 1960 or later (thereby excluding miners employed during the periods of highest exposure and focusing on miners who tend to have higher quality assessments of radon progeny exposures). We derived estimates of excess relative rate per 100 working level months (ERR/100 WLM) for mortality from lung cancer.
RESULTS
The analysis included
DISCUSSION
Estimates of association between radon progeny exposure and lung cancer mortality among relatively contemporary miners are coherent with estimates used to inform current protection guidelines. https://doi.org/10.1289/EHP10669.
Identifiants
pubmed: 35604341
doi: 10.1289/EHP10669
pmc: PMC9126132
doi:
Substances chimiques
Radon Daughters
0
Uranium
4OC371KSTK
Radon
Q74S4N8N1G
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
57010Subventions
Organisme : NIOSH CDC HHS
ID : R03 OH010946
Pays : United States
Organisme : ACL HHS
ID : R21OH011452
Pays : United States
Références
J Radiol Prot. 2021 Jun 01;41(2):
pubmed: 33823504
Int J Environ Res Public Health. 2013 Mar 07;10(3):963-79
pubmed: 23470882
Health Phys. 1994 Apr;66(4):450-3
pubmed: 8138413
Occup Environ Med. 2020 Mar;77(3):194-200
pubmed: 32005674
Ann ICRP. 2010 Feb;40(1):1-64
pubmed: 22108246
Radiat Prot Dosimetry. 2017 Nov 1;176(3):278-286
pubmed: 28204795
Radiat Prot Dosimetry. 2008;130(1):98-100
pubmed: 18397930
Radiat Res. 2011 Sep;176(3):375-87
pubmed: 21714633
Radiat Environ Biophys. 2012 Mar;51(1):15-22
pubmed: 22193911
Radiat Prot Dosimetry. 2020 Nov 27;191(2):171-175
pubmed: 33130900
Int J Epidemiol. 2021 May 17;50(2):633-643
pubmed: 33232447
Yale J Biol Med. 1988 May-Jun;61(3):195-214
pubmed: 3051700
Health Phys. 1991 Apr;60(4):489-95
pubmed: 2001944
Int J Epidemiol. 2010 Aug;39(4):980-7
pubmed: 19494089
Br J Cancer. 2012 Jun 19;107 Suppl 1:S3-7
pubmed: 22710676
Radiat Res. 2008 Feb;169(2):125-37
pubmed: 18220460
Occup Environ Med. 2015 Jul;72(7):536-42
pubmed: 25713154
IARC Sci Publ. 1987;(82):1-406
pubmed: 3329634
Br J Cancer. 2015 Nov 3;113(9):1367-9
pubmed: 26393888
Occup Environ Med. 2004 Nov;61(11):930-5
pubmed: 15477287
Int Arch Occup Environ Health. 2015 Aug;88(6):717-30
pubmed: 25410273
Health Phys. 2004 Nov;87(5):480-9
pubmed: 15551786
Health Phys. 2007 Apr;92(4):371-8
pubmed: 17351502
Am J Public Health. 1981 Mar;71(3):242-50
pubmed: 7468855
Health Phys. 2010 Jan;98(1):20-8
pubmed: 19959947
Health Phys. 2007 Feb;92(2):157-69
pubmed: 17220717
Am J Epidemiol. 2009 Mar 15;169(6):718-30
pubmed: 19208723
J Radiol Prot. 2019 Mar;39(1):136-149
pubmed: 30524032
Health Phys. 1991 Dec;61(6):745-52
pubmed: 1659563
Radiat Prot Dosimetry. 2014 Jul;160(1-3):124-7
pubmed: 24751983
Ann ICRP. 2020 Dec;49(1_suppl):57-67
pubmed: 32734762
Occup Environ Med. 2016 Dec;73(12):838-845
pubmed: 27651479
Radiat Res. 2010 Dec;174(6):773-85
pubmed: 21128801
Am J Ind Med. 2013 May;56(5):531-40
pubmed: 23450695
Radiat Res. 2010 Jan;173(1):79-90
pubmed: 20041762
Br J Cancer. 2012 Sep 25;107(7):1188-94
pubmed: 22929885
Am J Epidemiol. 1992 Nov 15;136(10):1232-40
pubmed: 1476145
Radiat Res. 2018 Feb;189(2):165-176
pubmed: 29215327
Radiat Prot Dosimetry. 2021 Aug 14;195(1):1-20
pubmed: 34278430
J Expo Anal Environ Epidemiol. 2002 May;12(3):197-203
pubmed: 12032816
Health Phys. 1993 Feb;64(2):120-31
pubmed: 8449705
J Radiol Prot. 2012 Sep;32(3):301-14
pubmed: 22809823
J Radiol Prot. 2012 Mar;32(1):85-100
pubmed: 22392893
Health Phys. 1976 Jun;30(6):433-7
pubmed: 955899