The interferon-β/STAT1 axis drives the collective invasion of skin squamous cell carcinoma with sealed intercellular spaces.
Journal
Oncogenesis
ISSN: 2157-9024
Titre abrégé: Oncogenesis
Pays: United States
ID NLM: 101580004
Informations de publication
Date de publication:
24 May 2022
24 May 2022
Historique:
received:
17
10
2021
accepted:
05
05
2022
revised:
17
04
2022
entrez:
23
5
2022
pubmed:
24
5
2022
medline:
24
5
2022
Statut:
epublish
Résumé
The process by which cancer cells invade as a cell cluster, known as collective invasion, is associated with metastasis and worse prognosis of cancer patients; therefore, inhibition of collective invasion is considered to improve cancer treatment. However, the cellular characteristics responsible for collective invasion remain largely unknown. Here, we successfully established subclones with various invasive potentials derived from human skin squamous carcinoma cells. The cell cluster of the highly invasive subclone had a hermetically sealed and narrow intercellular space. Interferon-β was localized to the sealed intercellular spaces, leading to collective invasion via the activation of signal transducer and activator of transcription 1 (STAT1). On the other hand, interferon-β was not localized to non-sealed and wide intercellular spaces of the cell cluster of low-invasive subclone with deficient STAT1 activity. In the mixed cell cluster of high- and low-invasive subclones, the high-invasive sub-clonal cells were located at the invasive front of the invasive protrusion, leading to collective invasion by the low-invasive sub-clonal cells. Tissue microarray analysis of human skin squamous cell carcinoma (SCC) also showed enrichment of STAT1 in the invasive front of SCCs. These findings indicate that the intercellular structure controls the potential for collective invasion via STAT1 regulation in SCC.
Identifiants
pubmed: 35606369
doi: 10.1038/s41389-022-00403-9
pii: 10.1038/s41389-022-00403-9
pmc: PMC9126940
doi:
Types de publication
Journal Article
Langues
eng
Pagination
27Subventions
Organisme : Japan Agency for Medical Research and Development (AMED)
ID : 20gm0810007h0005
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 21K07142
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 20J13568
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : 21K07141
Informations de copyright
© 2022. The Author(s).
Références
Nat Cell Biol. 2017 Mar;19(3):224-237
pubmed: 28218910
J Leukoc Biol. 2001 Dec;70(6):950-60
pubmed: 11739558
Breast Cancer Res Treat. 2015 Dec;154(3):563-71
pubmed: 26573830
Mol Cell Biol. 1997 Sep;17(9):5328-37
pubmed: 9271410
Sci Adv. 2020 Jul 24;6(30):eaaz6197
pubmed: 32832657
Cell. 2020 Oct 15;183(2):395-410.e19
pubmed: 33007268
J Cell Sci. 2012 Jun 1;125(Pt 11):2638-54
pubmed: 22344263
Cell. 2014 Aug 28;158(5):1110-1122
pubmed: 25171411
Nat Rev Cancer. 2021 Sep;21(9):592-604
pubmed: 34239104
Cancer Cell. 2015 Jan 12;27(1):15-26
pubmed: 25584892
Br J Cancer. 1995 Jul;72(1):134-9
pubmed: 7599042
Cell Adh Migr. 2011 Jul-Aug;5(4):360-5
pubmed: 21836391
Nat Rev Cancer. 2003 May;3(5):362-74
pubmed: 12724734
Oncogene. 2007 Aug 9;26(36):5214-28
pubmed: 17334396
Nat Commun. 2021 Feb 8;12(1):863
pubmed: 33558489
Nat Cell Biol. 2007 Dec;9(12):1392-400
pubmed: 18037882
Cell. 2013 Dec 19;155(7):1639-51
pubmed: 24332913
J Cell Biol. 1994 Nov;127(4):1049-60
pubmed: 7525601
Nat Cell Biol. 2012 Aug;14(8):777-83
pubmed: 22854810
J Cell Biol. 1990 Jul;111(1):153-69
pubmed: 1694855
JAKSTAT. 2013 Jul 1;2(3):e23931
pubmed: 24069549
Clin Exp Metastasis. 2010 Mar;27(3):133-40
pubmed: 20180146
Exp Cell Res. 1961;Suppl 8:174-87
pubmed: 13698424
Diagn Cytopathol. 2016 Feb;44(2):121-3
pubmed: 26681399
Immunity. 2012 Apr 20;36(4):503-14
pubmed: 22520844
Cytokine. 2017 Jan;89:12-20
pubmed: 26631912
J Biol Chem. 2001 Jun 1;276(22):19512-23
pubmed: 11278462
Oncogene. 2000 May 15;19(21):2619-27
pubmed: 10851061
Nat Rev Cancer. 2018 Apr;18(4):211-223
pubmed: 29422598
Oncogenesis. 2013 Aug 05;2:e59
pubmed: 23917221
Dev Biol Stand. 1982;52:87-94
pubmed: 6299862
Cancer Res. 1978 Sep;38(9):2651-60
pubmed: 354778
Proc Natl Acad Sci U S A. 1996 Jul 23;93(15):7673-8
pubmed: 8755534
Cancer Discov. 2015 Oct;5(10):1086-97
pubmed: 26209539
Biochem Biophys Res Commun. 2019 Jul 5;514(4):1115-1121
pubmed: 31101337
Int J Oncol. 2013 Oct;43(4):1111-6
pubmed: 23917355
Nat Rev Immunol. 2014 Jan;14(1):36-49
pubmed: 24362405
Cancer Res. 2008 Sep 15;68(18):7247-9
pubmed: 18794108
Nat Commun. 2017 May 12;8:15078
pubmed: 28497793
Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E854-63
pubmed: 26831077
Clin Exp Metastasis. 2017 Oct;34(6-7):421-429
pubmed: 28894989
Bioinformatics. 2007 Dec 1;23(23):3251-3
pubmed: 17644558
Oncogene. 2006 Jun 22;25(26):3670-9
pubmed: 16462767
Elife. 2013 Jun 25;2:e00747
pubmed: 23805382
Pathol Int. 2016 Apr;66(4):183-92
pubmed: 26897041
Histochem Cell Biol. 2006 Jul;126(1):45-56
pubmed: 16404573
Cell Rep. 2014 May 22;7(4):1156-67
pubmed: 24794433