Effectiveness of biomaterial-based combination strategies for spinal cord repair - a systematic review and meta-analysis of preclinical literature.
Journal
Spinal cord
ISSN: 1476-5624
Titre abrégé: Spinal Cord
Pays: England
ID NLM: 9609749
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
10
12
2020
accepted:
12
05
2022
revised:
10
05
2022
pubmed:
24
5
2022
medline:
3
12
2022
entrez:
23
5
2022
Statut:
ppublish
Résumé
Systematic review and meta-analysis of preclinical literature. To assess the effects of biomaterial-based combination (BMC) strategies for the treatment of Spinal Cord Injury (SCI), the effects of individual biomaterials in the context of BMC strategies, and the factors influencing their efficacy. To assess the effects of different preclinical testing paradigms in BMC strategies. We performed a systematic literature search of Embase, Web of Science and PubMed. All controlled preclinical studies describing an in vivo or in vitro model of SCI that tested a biomaterial in combination with at least one other regenerative strategy (cells, drugs, or both) were included. Two review authors conducted the study selection independently, extracted study characteristics independently and assessed study quality using a modified CAMARADES checklist. Effect size measures were combined using random-effects models and heterogeneity was explored using meta-regression with tau 134 publications were included, testing over 100 different BMC strategies. Overall, treatment with BMC therapies improved locomotor recovery by 25.3% (95% CI, 20.3-30.3; n = 102) and in vivo axonal regeneration by 1.6 SD (95% CI 1.2-2 SD; n = 117) in comparison with injury only controls. BMC strategies improve locomotor outcomes after experimental SCI. Our comprehensive study highlights gaps in current knowledge and provides a foundation for the design of future experiments.
Identifiants
pubmed: 35606413
doi: 10.1038/s41393-022-00811-z
pii: 10.1038/s41393-022-00811-z
pmc: PMC9712119
doi:
Substances chimiques
Biocompatible Materials
0
Types de publication
Systematic Review
Meta-Analysis
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1041-1049Informations de copyright
© 2022. The Author(s).
Références
Front Cell Neurosci. 2018 Jan 11;11:430
pubmed: 29375316
Exp Neurol. 2008 Feb;209(2):294-301
pubmed: 17617407
Biotechnol Bioeng. 2017 Feb;114(2):245-259
pubmed: 27531038
PLoS Biol. 2013 Dec;11(12):e1001738
pubmed: 24358022
Arch Bone Jt Surg. 2016 Jan;4(1):56-9
pubmed: 26894220
Biomed Mater. 2018 Apr 25;13(4):044105
pubmed: 29359704
Lancet Neurol. 2002 May;1(1):51-7
pubmed: 12849545
Nature. 2018 May;557(7705):343-350
pubmed: 29769671
Nature. 2018 Mar 7;555(7695):175-182
pubmed: 29517004
J Neurosci Methods. 2014 Jan 15;221:92-102
pubmed: 24099992
PLoS One. 2013 Aug 09;8(8):e71317
pubmed: 23951131
Neurorehabil Neural Repair. 2000;14(4):265-75
pubmed: 11402877
Biomed Mater. 2012 Apr;7(2):024101
pubmed: 22456684
Prog Neurobiol. 2014 Mar;114:25-57
pubmed: 24269804
Neural Regen Res. 2015 May;10(5):726-42
pubmed: 26109946
Eur J Neurosci. 2009 Jan;29(1):132-45
pubmed: 19120441
J Spinal Cord Med. 2013 May;36(3):174-90
pubmed: 23809587
Rev Neurosci. 2015;26(4):397-405
pubmed: 25870961
Expert Opin Biol Ther. 2017 May;17(5):529-541
pubmed: 28306359
Nat Med. 2007 May;13(5):561-6
pubmed: 17479102
Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3024-9
pubmed: 11867737
Stroke. 2004 May;35(5):1203-8
pubmed: 15060322
Neural Regen Res. 2018 May;13(5):809-810
pubmed: 29863007
Nat Methods. 2017 Nov;14(11):1024-1025
pubmed: 28960183
Polymers (Basel). 2011 Sep 1;3(3):1377-1397
pubmed: 22577513
J Neurotrauma. 2006 Mar-Apr;23(3-4):438-52
pubmed: 16629628
Tissue Eng Part A. 2016 May;22(9-10):733-41
pubmed: 27056081
World Neurosurg. 2019 Sep;129:e343-e351
pubmed: 31132502
Nat Med. 2018 May;24(4):484-490
pubmed: 29480894
J Neurotrauma. 2006 Mar-Apr;23(3-4):496-507
pubmed: 16629632
J Neurosci Methods. 2010 May 15;188(2):258-69
pubmed: 20219534
PLoS Biol. 2015 Oct 13;13(10):e1002273
pubmed: 26460723
Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E820-E829
pubmed: 28096400
J Biomed Mater Res B Appl Biomater. 2011 May;97(2):271-7
pubmed: 21384547
Spinal Cord. 2017 Aug;55(8):714-721
pubmed: 28117332
Neurosci Bull. 2013 Aug;29(4):445-59
pubmed: 23864367
Biotechnol Bioeng. 2016 Feb;113(2):253-9
pubmed: 26134352
Handb Clin Neurol. 2012;109:575-94
pubmed: 23098738