Repurposing drugs to treat cardiovascular disease in the era of precision medicine.
Journal
Nature reviews. Cardiology
ISSN: 1759-5010
Titre abrégé: Nat Rev Cardiol
Pays: England
ID NLM: 101500075
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
accepted:
22
04
2022
pubmed:
24
5
2022
medline:
19
10
2022
entrez:
23
5
2022
Statut:
ppublish
Résumé
Drug repurposing is the use of a given therapeutic agent for indications other than that for which it was originally designed or intended. The concept is appealing because of potentially lower development costs and shorter timelines than are needed to produce a new drug. To date, drug repurposing for cardiovascular indications has been opportunistic and driven by knowledge of disease mechanisms or serendipitous observation rather than by systematic endeavours to match an existing drug to a new indication. Innovations in two areas of personalized medicine - computational approaches to associate drug effects with disease signatures and predictive model systems to screen drugs for disease-modifying activities - support efforts that together create an efficient pipeline to systematically repurpose drugs to treat cardiovascular disease. Furthermore, new experimental strategies that guide the medicinal chemistry re-engineering of drugs could improve repurposing efforts by tailoring a medicine to its new indication. In this Review, we summarize the historical approach to repurposing and discuss the technological advances that have created a new landscape of opportunities.
Identifiants
pubmed: 35606425
doi: 10.1038/s41569-022-00717-6
pii: 10.1038/s41569-022-00717-6
pmc: PMC9125554
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
751-764Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL141084
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138539
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL152055
Pays : United States
Informations de copyright
© 2022. Springer Nature Limited.
Références
BMC Med Genomics. 2015;8 Suppl 2:S1
pubmed: 26044129
Pharmacol Res. 2021 Jul;169:105605
pubmed: 33965510
Front Endocrinol (Lausanne). 2019 Sep 18;10:617
pubmed: 31620081
Int J Bipolar Disord. 2021 Feb 1;9(1):5
pubmed: 33521889
J Am Coll Cardiol. 2021 Apr 20;77(15):1845-1855
pubmed: 33858620
Biochim Biophys Acta. 2016 Jul;1863(7 Pt B):1717-27
pubmed: 26952934
Pharmaceuticals (Basel). 2021 Jul 16;14(7):
pubmed: 34358112
Ann Rheum Dis. 2011 Jun;70(6):909-20
pubmed: 21378402
J Am Coll Cardiol. 2016 Apr 5;67(13):1544-1552
pubmed: 27150686
Nature. 2009 Nov 12;462(7270):175-81
pubmed: 19881490
EMBO J. 2014 Mar 3;33(5):409-17
pubmed: 24500035
JAMA. 2006 Jun 21;295(23):2727-41
pubmed: 16754727
JAMA Oncol. 2021 Mar 01;7(3):428-435
pubmed: 33475710
Heart. 2017 Aug;103(16):1264-1270
pubmed: 28280146
JCI Insight. 2020 Jun 4;5(11):
pubmed: 32369446
Medicine (Baltimore). 2018 Apr;97(15):e0409
pubmed: 29642208
Drug Discov Today. 2020 Sep;25(9):1569-1574
pubmed: 32554063
Biochem Pharmacol. 2020 Jul;177:113895
pubmed: 32145263
J Am Med Inform Assoc. 2003 May-Jun;10(3):252-9
pubmed: 12626374
Expert Opin Drug Discov. 2020 Jan;15(1):27-37
pubmed: 31570020
Nat Med. 2019 Jul;25(7):1116-1122
pubmed: 31263281
Nat Rev Drug Discov. 2022 May 30;:
pubmed: 35637317
J Am Med Inform Assoc. 2011 Sep-Oct;18(5):540-3
pubmed: 21846785
Circulation. 2012 Dec 4;126(23):2739-48
pubmed: 23129601
Nat Rev Drug Discov. 2019 Jun;18(6):463-477
pubmed: 30976107
Pediatrics. 2020 Dec;146(6):
pubmed: 33219052
J Chem Inf Model. 2021 Jun 20;:
pubmed: 34151561
Sci Transl Med. 2011 Aug 17;3(96):96ra76
pubmed: 21849664
N Engl J Med. 2019 Dec 26;381(26):2497-2505
pubmed: 31733140
JAMA Neurol. 2021 Feb 1;78(2):186-196
pubmed: 33226425
Front Physiol. 2020 Sep 15;11:568632
pubmed: 33041865
N Engl J Med. 2006 Mar 23;354(12):1264-72
pubmed: 16554528
Circulation. 2019 Mar 5;139(10):1289-1299
pubmed: 30586730
Blood Cells Mol Dis. 2009 Mar-Apr;42(2):159-66
pubmed: 19167250
Cell Chem Biol. 2021 Mar 18;28(3):271-282
pubmed: 33740432
J Am Coll Cardiol. 2006 Oct 3;48(7):1378-84
pubmed: 17010798
Nat Rev Drug Discov. 2011 Jun 24;10(7):507-19
pubmed: 21701501
J Cardiol. 2021 Jun;77(6):576-582
pubmed: 33272780
Comput Biol Chem. 2013 Dec;47:167-80
pubmed: 24121675
Eur J Heart Fail. 1999 Dec;1(4):401-6
pubmed: 10937954
Nat Biotechnol. 2004 May;22(5):595-9
pubmed: 15097998
Circulation. 2021 Aug 3;144(5):382-392
pubmed: 33928785
Nat Rev Drug Discov. 2019 Jan;18(1):41-58
pubmed: 30310233
Curr Biol. 2006 Jul 11;16(13):1366-72
pubmed: 16824925
J Biomol Struct Dyn. 2022 Feb;40(3):1101-1108
pubmed: 32948103
Obes Rev. 2011 May;12(5):e338-47
pubmed: 21438989
Sci Rep. 2015 Mar 09;5:8883
pubmed: 25748532
Cardiovasc Diabetol. 2011 Mar 16;10:22
pubmed: 21410975
Int Heart J. 2018 Sep 26;59(5):1096-1105
pubmed: 30101858
Nat Rev Drug Discov. 2019 Jan;18(1):1-2
pubmed: 29880920
Lancet. 1986 Mar 15;1(8481):575-80
pubmed: 2869302
Curr Atheroscler Rep. 2021 May 10;23(7):32
pubmed: 33970350
Theranostics. 2018 Sep 09;8(17):4750-4764
pubmed: 30279735
Sci Transl Med. 2017 Feb 15;9(377):
pubmed: 28202772
Circulation. 2011 Jan 4;123(1):23-30
pubmed: 21098441
Nat Rev Drug Discov. 2020 Feb;19(2):79-84
pubmed: 32020068
Circulation. 2015 Jan 20;131(3):289-99
pubmed: 25486933
Nat Commun. 2013;4:2410
pubmed: 24002024
Nat Rev Drug Discov. 2017 Aug;16(8):531-543
pubmed: 28685762
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15428-33
pubmed: 12434014
Science. 2008 Jul 11;321(5886):263-6
pubmed: 18621671
Science. 2013 Jul 5;341(6141):84-7
pubmed: 23828940
Acta Pharmacol Sin. 2017 Apr;38(4):488-497
pubmed: 28216620
N Engl J Med. 2012 Jan 26;366(4):339-47
pubmed: 22276823
Nat Metab. 2020 Oct;2(10):1135-1148
pubmed: 33067605
BMJ. 2003 Jun 28;326(7404):1423
pubmed: 12829554
Cell Stem Cell. 2019 Apr 4;24(4):579-591.e12
pubmed: 30853557
Clin Pharmacol Ther. 2010 Sep;88(3):335-8
pubmed: 20664535
Pharmacol Rev. 2020 Jan;72(1):320-342
pubmed: 31871214
J Clin Invest. 2018 Apr 2;128(4):1496-1508
pubmed: 29461977
J Rheumatol. 2012 Jul;39(7):1458-64
pubmed: 22660810
Cardiovasc Res. 2022 Jan 7;118(1):282-294
pubmed: 33386841
Lancet. 2020 Sep 19;396(10254):819-829
pubmed: 32877652
Sci Rep. 2015 Jul 09;5:11970
pubmed: 26155766
PLoS One. 2016 Feb 10;11(2):e0147215
pubmed: 26863229
J Exp Clin Cancer Res. 2021 Jul 24;40(1):241
pubmed: 34303383
Blood. 2013 Oct 24;122(17):3074-81
pubmed: 23996087
Nat Commun. 2021 Feb 24;12(1):1279
pubmed: 33627659
Nature. 2010 Aug 5;466(7307):707-13
pubmed: 20686565
Nucleic Acids Res. 2014 Jul;42(Web Server issue):W32-8
pubmed: 24792161
Bioinformatics. 2019 Sep 1;35(17):3176-3177
pubmed: 30629124
PLoS Biol. 2017 Mar 21;15(3):e2001882
pubmed: 28323820
Cell Rep. 2014 Nov 6;9(3):810-21
pubmed: 25437537
Curr Cardiol Rep. 2021 May 7;23(6):62
pubmed: 33961142
Circ Genom Precis Med. 2018 Aug;11(8):e001977
pubmed: 30354342
Cell Stem Cell. 2020 Nov 5;27(5):813-821.e6
pubmed: 32931730
BMC Cardiovasc Disord. 2017 Jun 12;17(1):150
pubmed: 28606099
Regen Ther. 2019 Jul 26;11:143-166
pubmed: 31384636
J Psychopharmacol. 2015 Dec;29(12):1221-30
pubmed: 26349559
Arthritis Rheumatol. 2017 Jun;69(6):1154-1164
pubmed: 28245350
Dig Dis Sci. 2014 Jul;59(7):1535-43
pubmed: 24504592
Clin Ther. 2019 Jan;41(1):41-48
pubmed: 30591286
N Engl J Med. 1999 Nov 18;341(21):1565-71
pubmed: 10564685
F1000Res. 2020 Aug 7;9:
pubmed: 32850117
J Med Chem. 2021 May 13;64(9):5384-5403
pubmed: 33942619
CMAJ. 2017 Feb 6;189(5):E194-E203
pubmed: 28246265
Brief Bioinform. 2005 Sep;6(3):277-86
pubmed: 16212775
Br J Cancer. 2021 Mar;124(6):1072-1078
pubmed: 33398062
Comput Struct Biotechnol J. 2020 Jun 12;18:1639-1650
pubmed: 32670504
Nat Med. 2021 Nov;27(11):1954-1960
pubmed: 34711976
Nat Rev Drug Discov. 2020 May;19(5):353-364
pubmed: 31801986
Cancer Prev Res (Phila). 2014 Sep;7(9):867-85
pubmed: 24985407
Ther Adv Urol. 2012 Oct;4(5):233-51
pubmed: 23024705
NPJ Genom Med. 2021 Jun 16;6(1):51
pubmed: 34135346
Naunyn Schmiedebergs Arch Pharmacol. 2021 Mar;394(3):533-543
pubmed: 33064167
Am J Gastroenterol. 2006 Feb;101(2):399-402
pubmed: 16454849
Eur Heart J. 2021 Feb 21;42(8):813-821
pubmed: 33388753
Eur Heart J. 2020 Nov 14;41(43):4181-4187
pubmed: 32548624
J Am Coll Cardiol. 2015 Apr 21;65(15):1567-82
pubmed: 25881939
Nat Biotechnol. 2012 Apr 10;30(4):317-20
pubmed: 22491277
BMJ Open. 2019 Dec 2;9(12):e033131
pubmed: 31796494
SLAS Discov. 2019 Jan;24(1):1-24
pubmed: 30196745
BMC Bioinformatics. 2017 May 31;18(Suppl 7):226
pubmed: 28617219
Sci Transl Med. 2014 Dec 10;6(266):266ra170
pubmed: 25504881
Vascul Pharmacol. 2019 Feb;113:1-8
pubmed: 30391545
J Am Med Inform Assoc. 2015 Jan;22(1):179-91
pubmed: 25053577
J Am Coll Cardiol. 2020 Aug 18;76(7):797-808
pubmed: 32792077
Science. 2006 Apr 7;312(5770):117-21
pubmed: 16601194
Front Pharmacol. 2017 Feb 06;8:36
pubmed: 28220073
Eur Heart J. 2012 Jun;33(12):1491-9
pubmed: 21920963
JAMA Intern Med. 2018 Nov 1;178(11):1451-1457
pubmed: 30264133
J Biol Chem. 2016 Apr 1;291(14):7242-55
pubmed: 26846851
Cell Rep. 2020 Sep 8;32(10):108117
pubmed: 32905764
Sci Transl Med. 2021 Jul 21;13(603):
pubmed: 34290054