Dynamic functional connectivity patterns associated with dementia risk.
Cardiovascular risk factors
Cognition
Cognitive reserve
Dementia risk
Dynamic functional network connectivity
Lifestyle
Sliding window analysis
Journal
Alzheimer's research & therapy
ISSN: 1758-9193
Titre abrégé: Alzheimers Res Ther
Pays: England
ID NLM: 101511643
Informations de publication
Date de publication:
23 05 2022
23 05 2022
Historique:
received:
12
01
2022
accepted:
06
04
2022
entrez:
23
5
2022
pubmed:
24
5
2022
medline:
26
5
2022
Statut:
epublish
Résumé
This study assesses the relationships between dynamic functional network connectivity (DFNC) and dementia risk. DFNC of the default mode (DMN), salience (SN), and executive control networks was assessed in 127 cognitively unimpaired older adults. Stepwise regressions were performed with dementia risk and protective factors and biomarkers as predictors of DFNC. Associations were found between times spent in (i) a "weakly connected" state and lower self-reported engagement in early- and mid-life cognitive activity and higher LDL cholesterol; (ii) a "SN-negatively connected" state and higher blood pressure, higher depression score, and lower body mass index (BMI); (iii) a "strongly connected" state and higher self-reported engagement in early-life cognitive activity, Preclinical Alzheimer's cognitive composite-5 score, and BMI; and (iv) a "DMN-negatively connected" state and higher self-reported engagement in early- and mid-life stimulating activities and lower LDL cholesterol and blood pressure. The lower number of state transitions was associated with lower brain perfusion. DFNC states are differentially associated with dementia risk and could underlie reserve.
Sections du résumé
BACKGROUND
This study assesses the relationships between dynamic functional network connectivity (DFNC) and dementia risk.
METHODS
DFNC of the default mode (DMN), salience (SN), and executive control networks was assessed in 127 cognitively unimpaired older adults. Stepwise regressions were performed with dementia risk and protective factors and biomarkers as predictors of DFNC.
RESULTS
Associations were found between times spent in (i) a "weakly connected" state and lower self-reported engagement in early- and mid-life cognitive activity and higher LDL cholesterol; (ii) a "SN-negatively connected" state and higher blood pressure, higher depression score, and lower body mass index (BMI); (iii) a "strongly connected" state and higher self-reported engagement in early-life cognitive activity, Preclinical Alzheimer's cognitive composite-5 score, and BMI; and (iv) a "DMN-negatively connected" state and higher self-reported engagement in early- and mid-life stimulating activities and lower LDL cholesterol and blood pressure. The lower number of state transitions was associated with lower brain perfusion.
CONCLUSION
DFNC states are differentially associated with dementia risk and could underlie reserve.
Identifiants
pubmed: 35606867
doi: 10.1186/s13195-022-01006-7
pii: 10.1186/s13195-022-01006-7
pmc: PMC9128270
doi:
Substances chimiques
Cholesterol, LDL
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
72Investigateurs
Eider M Arenaza-Urquijo
(EM)
Florence Allais
(F)
Claire André
(C)
Julien Asselineau
(J)
Alexandre Bejanin
(A)
Pierre Champetier
(P)
Gaël Chételat
(G)
Anne Chocat
(A)
Sophie Dautricourt
(S)
Robin de Flores
(R)
Marion Delarue
(M)
Stéphanie Egret
(S)
Francesca Felisatti
(F)
Eglantine Ferrand Devouge
(EF)
Eric Frison
(E)
Julie Gonneaud
(J)
Marc Heidmann
(M)
Thien Huong Tran
(TH)
Elizabeth Kuhn
(E)
Gwendoline le Du
(G)
Brigitte Landeau
(B)
Valérie Lefranc
(V)
Antoine Lutz
(A)
Florence Mezenge
(F)
Inès Moulinet
(I)
Valentin Ourry
(V)
Cassandre Palix
(C)
Léo Paly
(L)
Géraldine Poisnel
(G)
Anne Quillard
(A)
Géraldine Rauchs
(G)
Stéphane Rehel
(S)
Florence Requier
(F)
Edelweiss Touron
(E)
Denis Vivien
(D)
Caitlin Ware
(C)
Sebastian Baez Lugo
(SB)
Olga Klimecki
(O)
Patrik Vuilleumier
(P)
Thorsten Barnhofer
(T)
Fabienne Collette
(F)
Eric Salmon
(E)
Vincent de la Sayette
(V)
Pascal Delamillieure
(P)
Martine Batchelor
(M)
Axel Beaugonin
(A)
Francis Gheysen
(F)
Harriet Demnitz-King
(H)
Natalie Marchant
(N)
Tim Whitfield
(T)
Corinne Schimmer
(C)
Miranka Wirth
(M)
Informations de copyright
© 2022. The Author(s).
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