Targeting Necroptosis as a Promising Therapy for Alzheimer's Disease.

Alzheimer Disease / drug therapy Apoptosis Humans Necroptosis Necrosis Protein Kinases / metabolism Receptor-Interacting Protein Serine-Threonine Kinases / metabolism
Alzheimer’s disease MLKL RIPK1 RIPK3 necroptosis therapy

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
15 06 2022
Historique:
pubmed: 25 5 2022
medline: 18 6 2022
entrez: 24 5 2022
Statut: ppublish

Résumé

Alzheimer's disease (AD) is an irreversible and progressive neurodegenerative disorder featured by memory loss and cognitive default. However, there has been no effective therapeutic approach to prevent the development of AD and the available therapies are only to alleviate some symptoms with limited efficacy and severe side effects. Necroptosis is a new kind of cell death, being regarded as a genetically programmed and regulated pattern of necrosis. Increasing evidence reveals that necroptosis is tightly related to the occurrence and development of AD. This review aims to summarize the potential role of necroptosis in AD progression and the therapeutic capacity of targeting necroptosis for AD patients.

Identifiants

DOI: 10.1021/acschemneuro.2c00172 PMID: 35607807
pubmed: 35607807
doi: 10.1021/acschemneuro.2c00172
doi:

Substances chimiques

Protein Kinases EC 2.7.-
Receptor-Interacting Protein Serine-Threonine Kinases EC 2.7.11.1

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1697-1713

Auteurs

Wenli Zhao (W)

School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China.

Yue Liu (Y)

School of Pharmacy, Second Military Medical University, Shanghai 200433, China.

Lijuan Xu (L)

School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China.

Yuan He (Y)

Tongji University Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200070, China.

Zhenyu Cai (Z)

School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China.
Tongji University Cancer Center, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200070, China.

Jianqiang Yu (J)

School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China.

Wannian Zhang (W)

School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China.

Chengguo Xing (C)

Department of Medicinal Chemistry, University of Florida, 1345 Center Drive, Gainesville, Florida 32610, United States.
ORCID: 0000-0002-4266-6236

Chunlin Zhuang (C)

School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China.
ORCID: 0000-0002-0569-5708

Zhuo Qu (Z)

School of Pharmacy, Ningxia Medical University, 1160 Shengli Street, Yinchuan 750004, China.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Targeting Necroptosis as a Promising Therapy...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Targeting Necroptosis as a Promising Therapy...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Targeting Necroptosis as a Promising Therapy...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Nécroptose › Targeting Necroptosis as a Promising Therapy...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Targeting Necroptosis as a Promising Therapy...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Protein kinases › Targeting Necroptosis as a Promising Therapy...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Receptor-Interacting Protein Serine-Threonine Kinases › Targeting Necroptosis as a Promising Therapy...