Engineering microbial consortia with rationally designed cellular interactions.
Journal
Current opinion in biotechnology
ISSN: 1879-0429
Titre abrégé: Curr Opin Biotechnol
Pays: England
ID NLM: 9100492
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
06
12
2021
revised:
22
03
2022
accepted:
03
04
2022
pubmed:
25
5
2022
medline:
17
8
2022
entrez:
24
5
2022
Statut:
ppublish
Résumé
Synthetic microbial consortia represent a frontier of synthetic biology that promises versatile engineering of cellular functions. They are primarily developed through the design and construction of cellular interactions that coordinate individual dynamics and generate collective behaviors. Here we review recent advances in the engineering of synthetic communities through cellular-interaction programming. We first examine fundamental building blocks for intercellular communication and unidirectional positive and negative interactions. We then recap the assembly of the building blocks for creating bidirectional interactions in two-species ecosystems, which is followed by the discussion of engineering toward complex communities with increasing species numbers, under spatial contexts, and via model-guided design. We conclude by summarizing major challenges and future opportunities of engineered microbial ecosystems.
Identifiants
pubmed: 35609504
pii: S0958-1669(22)00064-7
doi: 10.1016/j.copbio.2022.102730
pmc: PMC10129393
mid: NIHMS1893172
pii:
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
102730Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM133579
Pays : United States
Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
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