Design of silica nanocarriers: Tuning the release to embryonic stem cells by simple strategies.
Chitosan
Drug delivery
Fibroblasts
Mesopores
Nanoparticles
Pluripotent stem cells
Journal
Journal of biotechnology
ISSN: 1873-4863
Titre abrégé: J Biotechnol
Pays: Netherlands
ID NLM: 8411927
Informations de publication
Date de publication:
20 Jul 2022
20 Jul 2022
Historique:
received:
30
08
2021
revised:
11
04
2022
accepted:
18
05
2022
pubmed:
25
5
2022
medline:
22
6
2022
entrez:
24
5
2022
Statut:
ppublish
Résumé
The design of mesoporous silica nanoparticles (MSNs) for drug delivery is attracting increasing interest. Controlled release of their cargo is usually mediated by diffusion and erosion mechanisms, which might not reach the expected therapeutic effects. Here, we report the development and characterization of MSNs which modulate the cargo release in different cell models: fibroblasts and embryonic stem cells. Based on a double strategy: the presence of multimodal pore channels and a chitosan coating, we demonstrated a modulated release. Our results show that MSNs could be used for controlled drug delivery in different cell types, showing the potential of improving pluripotent stem cells differentiation and reprogramming protocols with promising applications in biomedicine.
Identifiants
pubmed: 35609734
pii: S0168-1656(22)00116-X
doi: 10.1016/j.jbiotec.2022.05.008
pii:
doi:
Substances chimiques
Drug Carriers
0
Silicon Dioxide
7631-86-9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
19-27Informations de copyright
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