Oxysterols profiles in zebrafish (Danio rerio) embryos exposed to bisphenol A.

Animals Benzhydryl Compounds / metabolism Embryo, Nonmammalian / metabolism Oxysterols / metabolism Phenols Tandem Mass Spectrometry Water Pollutants, Chemical / metabolism Zebrafish / metabolism
Bisphenol A Carbamazepine Hydrogen peroxide Ketoconazole Oxysterols Zebrafish embryos

Journal

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483

Informations de publication

Date de publication:
Jul 2022
Historique:
received: 14 12 2021
revised: 06 05 2022
accepted: 17 05 2022
pubmed: 25 5 2022
medline: 18 6 2022
entrez: 24 5 2022
Statut: ppublish

Résumé

Oxysterols are cholesterol oxidation products and bioactive lipids involved in developmental signalling pathways, embryonic and postembryonic tissue patterning and homeostasis. The embryonic period is a very sensitive window of exposure to bisphenol A (BPA), hence the role of BPA on the levels of oxysterols in the very early stages of zebrafish embryogenesis is a relevant novel field of investigation. To compare the role of BPA on oxysterols levels in zebrafish embryos at 8 and 24 h post fertilization (hpf) with cytochromes P450 (CYPs)-modulating chemicals (carbamazepine, ketoconazole, and hydrogen peroxide). Upon a dose range finding, zebrafish embryos were exposed to environmentally relevant (0.04 μM) and toxicological (17.5 μM) BPA concentrations. Seven oxysterols were profiled by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Similarly to the CYPs-modulating chemicals, BPA caused: i) no significant changes at 8 hpf and ii) a dose-dependent increase of total oxysterols at 24 hpf, with 27-hydroxycholesterol as the most regulated oxysterol. In the first day post-fertilization of the zebrafish embryos, the role of BPA alike a CYPs-modulating chemical was confirmed by the similar oxysterol changes observed with the already known CYPs-modulating chemicals.

Identifiants

DOI: 10.1016/j.fct.2022.113166 PMID: 35609738
pubmed: 35609738
pii: S0278-6915(22)00364-7
doi: 10.1016/j.fct.2022.113166
pii:
doi:

Substances chimiques

Benzhydryl Compounds 0
Oxysterols 0
Phenols 0
Water Pollutants, Chemical 0
bisphenol A MLT3645I99

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113166

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Anton Vremere (A)

Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Italy; Dpt. of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità - ISS, Rome, Italy. Electronic address: avremere@unite.it.

Carmine Merola (C)

Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Italy. Electronic address: cmerola@unite.it.

Federico Fanti (F)

Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Italy. Electronic address: ffanti@unite.it.

Manuel Sergi (M)

Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Italy. Electronic address: msergi@unite.it.

Monia Perugini (M)

Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Italy. Electronic address: mperugini@unite.it.

Dario Compagnone (D)

Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Italy. Electronic address: dcompagnone@unite.it.

Milena Mikhail (M)

Dpt. of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità - ISS, Rome, Italy. Electronic address: milena.mikhail@iss.it.

Stefano Lorenzetti (S)

Dpt. of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità - ISS, Rome, Italy. Electronic address: stefano.lorenzetti@iss.it.

Michele Amorena (M)

Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, Italy. Electronic address: mamorena@unite.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Oxysterols profiles in zebrafish (Danio rerio)...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzhydryliques › Oxysterols profiles in zebrafish (Danio rerio)...
questionsmedicales.fr › Structures de l'embryon › Embryon non mammalien › Oxysterols profiles in zebrafish (Danio rerio)...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Oxystérols › Oxysterols profiles in zebrafish (Danio rerio)...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Oxysterols profiles in zebrafish (Danio rerio)...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Oxysterols profiles in zebrafish (Danio rerio)...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Polluants de l'eau › Polluants chimiques de l'eau › Oxysterols profiles in zebrafish (Danio rerio)...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Oxysterols profiles in zebrafish (Danio rerio)...