Prevalence and prospective evaluation of cognitive dysfunctions after SARS due to SARS-CoV-2 virus. The COgnitiVID study.
COVID-19
Cognitive disorder
Critical care syndrome
Executive function
SARS-CoV-2
Journal
Revue neurologique
ISSN: 0035-3787
Titre abrégé: Rev Neurol (Paris)
Pays: France
ID NLM: 2984779R
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
10
08
2021
revised:
03
03
2022
accepted:
21
03
2022
pubmed:
25
5
2022
medline:
12
10
2022
entrez:
24
5
2022
Statut:
ppublish
Résumé
COVID-19 due to SARS-CoV-2 virus is a new cause of severe acute respiratory syndrome (SARS). Little is known about the short-term cognitive prognosis for these patients. We prospectively evaluated basic cognitive functions shortly after care in the intensive care unit (ICU) and three months later in post-ICU COVID-19 patients. We performed a prospective single-center study in our institution in Paris. Patients with SARS-CoV-2 SARS were prospectively recruited via our ICU. Patients were evaluated using standardized cognitive tests at baseline and at three months' follow-up. Our primary endpoint was the evolution of the following five global tests: MMSE, FAB, oral naming test, Dubois five words test and MADRS. We explored 13 patients at baseline and follow-up. All patients had cognitive impairment at baseline but they all improved at three months, significantly on two of the five global tests after Bonferroni correction for multiple testing: MMSE (median 18 (IQR [15-22]) and 27 (IQR [27-29]) respectively, P=0.002) and FAB test (median 14 (IQR [14-17]) and 17 (IQR [17,18]) respectively, P=0.002). We report here the first longitudinal data on short-term cognitive impairment after intensive care in COVID-19 patients. We found acute and short-term cognitive impairment but significant improvement at three months. This pattern does not seem to differ from other causes of post-intensive care syndrome.
Identifiants
pubmed: 35610098
pii: S0035-3787(22)00616-6
doi: 10.1016/j.neurol.2022.03.014
pmc: PMC9123423
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
802-807Informations de copyright
Copyright © 2022 Elsevier Masson SAS. All rights reserved.
Références
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Eur J Neurol. 2020 Dec;27(12):2651-2657
pubmed: 32881133
Clin Neuropsychol. 2020 Oct - Nov;34(7-8):1453-1479
pubmed: 32901580
N Engl J Med. 2020 Apr 30;382(18):1708-1720
pubmed: 32109013
Neurology. 2000 Dec 12;55(11):1621-6
pubmed: 11113214
Br J Psychiatry. 1979 Apr;134:382-9
pubmed: 444788
N Engl J Med. 2013 Oct 3;369(14):1306-16
pubmed: 24088092
J Transl Int Med. 2017 Jun 30;5(2):90-92
pubmed: 28721340
J Neurol Neurosurg Psychiatry. 2021 May;92(5):567-568
pubmed: 33219042
Front Neurol. 2021 May 17;12:643646
pubmed: 34079511
Int J Environ Res Public Health. 2021 May 31;18(11):
pubmed: 34072951
Am J Respir Crit Care Med. 2012 Jun 15;185(12):1307-15
pubmed: 22492988
JAMA. 2010 Oct 27;304(16):1787-94
pubmed: 20978258
Intensive Care Med. 2009 May;35(5):796-809
pubmed: 19165464
N Engl J Med. 2020 Jun 4;382(23):2268-2270
pubmed: 32294339
J Head Trauma Rehabil. 2016 May-Jun;31(3):E10-20
pubmed: 26394296
Br J Sports Med. 2020 Aug;54(16):949-959
pubmed: 32475821
Ann Intern Med. 2021 Mar;174(3):316-325
pubmed: 33226861
Eur Geriatr Med. 2020 Oct;11(5):857-862
pubmed: 32666303
Front Neurol. 2020 Nov 05;11:574004
pubmed: 33224088
Cortex. 1996 Jun;32(2):241-59
pubmed: 8800613