In vivo multi spectral colonoscopy in mice.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
24 05 2022
24 05 2022
Historique:
received:
01
10
2021
accepted:
04
05
2022
entrez:
24
5
2022
pubmed:
25
5
2022
medline:
27
5
2022
Statut:
epublish
Résumé
Multi- and hyperspectral endoscopy are possibilities to improve the endoscopic detection of neoplastic lesions in the colon and rectum during colonoscopy. However, most studies in this context are performed on histological samples/biopsies or ex vivo. This leads to the question if previous results can be transferred to an in vivo setting. Therefore, the current study evaluated the usefulness of multispectral endoscopy in identifying neoplastic lesions in the colon. The data set consists of 25 mice with colonic neoplastic lesions and the data analysis is performed by machine learning. Another question addressed was whether adding additional spatial features based on Gauss-Laguerre polynomials leads to an improved detection rate. As a result, detection of neoplastic lesions was achieved with an MCC of 0.47. Therefore, the classification accuracy of multispectral colonoscopy is comparable with hyperspectral colonoscopy in the same spectral range when additional spatial features are used. Moreover, this paper strongly supports the current path towards the application of multi/hyperspectral endoscopy in clinical settings and shows that the challenges from transferring results from ex vivo to in vivo endoscopy can be solved.
Identifiants
pubmed: 35610504
doi: 10.1038/s41598-022-12794-1
pii: 10.1038/s41598-022-12794-1
pmc: PMC9130268
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8753Informations de copyright
© 2022. The Author(s).
Références
J Biomed Opt. 2013 Feb;18(2):26010
pubmed: 23389679
Sci Rep. 2020 Feb 26;10(1):3546
pubmed: 32103066
Sci Rep. 2019 May 17;9(1):7512
pubmed: 31101855
J Biophotonics. 2016 Mar;9(3):235-45
pubmed: 26033881
Gastroenterology. 2010 Dec;139(6):1837-1843.e1
pubmed: 20955705
Am J Gastroenterol. 2002 Dec;97(12):3182-5
pubmed: 12492208
Nat Protoc. 2007;2(8):1998-2004
pubmed: 17703211
J Biomed Opt. 2019 Jan;24(1):1-9
pubmed: 30701726
J Biomed Opt. 2014 Jan;19(1):10901
pubmed: 24441941
Clin Gastroenterol Hepatol. 2011 Jan;9(1):42-6
pubmed: 20888435
Best Pract Res Clin Gastroenterol. 2015 Feb;29(1):97-111
pubmed: 25743459
J Biophotonics. 2017 Apr;10(4):553-564
pubmed: 27403639
Diagnostics (Basel). 2021 Sep 30;11(10):
pubmed: 34679508
Sci Rep. 2020 Aug 4;10(1):13129
pubmed: 32753653
J Clin Med. 2019 Jan 01;8(1):
pubmed: 30609685
World J Gastrointest Endosc. 2015 Jun 10;7(6):659-64
pubmed: 26078834
J Biomed Opt. 2015 Jan;20(1):016017
pubmed: 25604546
J Biomed Opt. 2011 May;16(5):056005
pubmed: 21639573
Gut. 2005 Jul;54(7):950-4
pubmed: 15951540
Endoscopy. 2008 Apr;40(4):284-90
pubmed: 18389446