Effects of Senegal haplotype (
Senegal haplotype
albuminuria
alpha-thalassemia
glomerular filtration rate
kidney dysfunction
Journal
International journal of biochemistry and molecular biology
ISSN: 2152-4114
Titre abrégé: Int J Biochem Mol Biol
Pays: United States
ID NLM: 101532076
Informations de publication
Date de publication:
2022
2022
Historique:
received:
06
11
2021
accepted:
06
03
2022
entrez:
25
5
2022
pubmed:
26
5
2022
medline:
26
5
2022
Statut:
epublish
Résumé
Sickle cell anemia (SCA) can cause substantial kidney dysfunction resulting in sickle cell nephropathy, which may be affected by the presence of modifier genes. This study evaluates the effects of some modifier genes on sickle cell nephropathy. Patients living with SCA were recruited. Alpha-thalassemia (3.7kb The number of patients living with SCA included in this study was 162 with a median age of 20 years [minimum-maximum: 4-57] and a female frequency of 53.21%. Senegal haplotype, All four variants displayed a protective effect against albuminuria stage A2. The combination alpha-thalassemia -
Types de publication
Journal Article
Langues
eng
Pagination
5-16Subventions
Organisme : NHLBI NIH HHS
ID : U24 HL135600
Pays : United States
Informations de copyright
IJBMB Copyright © 2022.
Déclaration de conflit d'intérêts
None.
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