Disentangling Alzheimer's disease neurodegeneration from typical brain ageing using machine learning.
Alzheimer’s disease
MRI biomarker
amyloid
brain ageing
machine learning
Journal
Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125
Informations de publication
Date de publication:
2022
2022
Historique:
received:
17
02
2022
revised:
17
02
2022
accepted:
04
05
2022
entrez:
25
5
2022
pubmed:
26
5
2022
medline:
26
5
2022
Statut:
epublish
Résumé
Neuroimaging biomarkers that distinguish between changes due to typical brain ageing and Alzheimer's disease are valuable for determining how much each contributes to cognitive decline. Supervised machine learning models can derive multivariate patterns of brain change related to the two processes, including the Spatial Patterns of Atrophy for Recognition of Alzheimer's Disease (SPARE-AD) and of Brain Aging (SPARE-BA) scores investigated herein. However, the substantial overlap between brain regions affected in the two processes confounds measuring them independently. We present a methodology, and associated results, towards disentangling the two. T
Identifiants
pubmed: 35611306
doi: 10.1093/braincomms/fcac117
pii: fcac117
pmc: PMC9123890
doi:
Types de publication
Journal Article
Langues
eng
Pagination
fcac117Subventions
Organisme : NIA NIH HHS
ID : P30 AG066507
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG068057
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG059869
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054409
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG072979
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG026276
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG033655
Pays : United States
Informations de copyright
© The Author(s) 2022. Published by Oxford University Press on behalf of the Guarantors of Brain.
Références
Neuroimage. 2020 Dec;223:117248
pubmed: 32860881
Ann Neurol. 2009 Apr;65(4):403-13
pubmed: 19296504
Front Neurol. 2019 Aug 14;10:789
pubmed: 31474922
Neuroimage. 2020 Mar;208:116450
pubmed: 31821869
Alzheimers Res Ther. 2014 Nov 21;6(9):82
pubmed: 25419243
Arch Clin Neuropsychol. 2004 Mar;19(2):203-14
pubmed: 15010086
Neurology. 2010 Sep 28;75(13):1195-202
pubmed: 20739645
Trends Neurosci. 2017 Dec;40(12):681-690
pubmed: 29074032
Sci Rep. 2019 Dec 13;9(1):19024
pubmed: 31836810
Mol Psychiatry. 2019 Feb;24(2):266-281
pubmed: 29892055
Neuroimage. 2013 Sep;78:270-83
pubmed: 23583748
Front Aging Neurosci. 2018 Dec 11;10:408
pubmed: 30618715
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
Nat Commun. 2021 Sep 9;12(1):5346
pubmed: 34504080
Cereb Cortex. 2012 Sep;22(9):1993-2004
pubmed: 22038908
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Front Med (Lausanne). 2018 Mar 12;5:61
pubmed: 29662881
Transl Psychiatry. 2016 Apr 05;6:e775
pubmed: 27045845
Neuroimage. 2013 Aug 1;76:332-44
pubmed: 23507382
Neurobiol Aging. 2020 Mar;87:44-48
pubmed: 31843257
Acad Radiol. 2013 Dec;20(12):1566-76
pubmed: 24200484
Alzheimers Dement. 2015 May;11(5):549-60
pubmed: 25282381
Front Aging Neurosci. 2013 Oct 11;5:55
pubmed: 24130528
Front Aging Neurosci. 2021 Feb 12;13:631770
pubmed: 33643025
Ann Neurol. 2012 Oct;72(4):578-86
pubmed: 23109153
Alzheimer Dis Assoc Disord. 1997;11 Suppl 2:S13-21
pubmed: 9236948
Prog Neurobiol. 2014 Jun;117:20-40
pubmed: 24548606
Alzheimers Dement. 2019 Oct;15(10):1286-1295
pubmed: 31495603
J Neuropathol Exp Neurol. 2012 Apr;71(4):266-73
pubmed: 22437338
Aging Dis. 2020 May 9;11(3):618-628
pubmed: 32489706
Neuroimage. 2016 Feb 15;127:186-195
pubmed: 26679328
Brain. 2009 Aug;132(Pt 8):2026-35
pubmed: 19416949
Hum Brain Mapp. 2021 Jun 1;42(8):2332-2346
pubmed: 33738883
J Mol Neurosci. 2001 Oct;17(2):101-18
pubmed: 11816784
Arch Gen Psychiatry. 1983 Jul;40(7):812
pubmed: 6860082
PLoS One. 2013 Jun 27;8(6):e67346
pubmed: 23826273
Neurology. 2013 Nov 12;81(20):1753-8
pubmed: 24132375
Neuropsychology. 2009 Sep;23(5):541-50
pubmed: 19702408
Science. 1993 Aug 13;261(5123):921-3
pubmed: 8346443
Neuroimage. 2017 Dec;163:115-124
pubmed: 28765056
Neural Regen Res. 2018 Oct;13(10):1719-1730
pubmed: 30136683
J Magn Reson Imaging. 2008 Apr;27(4):685-91
pubmed: 18302232
PLoS One. 2020 Jul 29;15(7):e0234255
pubmed: 32726311
Semin Cell Dev Biol. 2021 Aug;116:180-193
pubmed: 33509689
Alzheimers Res Ther. 2021 Apr 19;13(1):82
pubmed: 33875021
Acta Neuropathol. 2011 May;121(5):571-87
pubmed: 21516511
Neuroimaging Clin N Am. 2005 Nov;15(4):869-77, xi-xii
pubmed: 16443497
Am J Psychiatry. 1984 Nov;141(11):1356-64
pubmed: 6496779
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
BMC Geriatr. 2003 Dec 19;3:7
pubmed: 14683526
Brain. 2020 Jul 1;143(7):2312-2324
pubmed: 32591831
J Gerontol. 1966 Oct;21(4):575-80
pubmed: 5918312
Lancet Neurol. 2017 Aug;16(8):661-676
pubmed: 28721928
Brain. 2016 Apr;139(Pt 4):1164-79
pubmed: 26912649
Commun Biol. 2020 Jul 6;3(1):352
pubmed: 32632135
IEEE Trans Med Imaging. 2010 Jun;29(6):1310-20
pubmed: 20378467
Alzheimers Dement. 2021 Jan;17(1):89-102
pubmed: 32920988
Nat Commun. 2019 Nov 27;10(1):5409
pubmed: 31776335
Exp Mol Med. 2019 May 9;51(5):1-10
pubmed: 31073121
Neuroimage. 2019 Oct 15;200:528-539
pubmed: 31201988
Mol Psychiatry. 2021 Aug;26(8):3829-3838
pubmed: 31822815
Neurobiol Aging. 2011 Dec;32(12):2322.e19-27
pubmed: 20594615
Neurology. 2016 Aug 2;87(5):539-47
pubmed: 27371494
Neuropsychology. 2005 Mar;19(2):199-211
pubmed: 15769204
J Cogn Neurosci. 2007 Sep;19(9):1498-507
pubmed: 17714011