Virologic and Immunologic Characterization of COVID-19 Recrudescence after Nirmatrelvir/Ritonavir Treatment.


Journal

Research square
Titre abrégé: Res Sq
Pays: United States
ID NLM: 101768035

Informations de publication

Date de publication:
18 May 2022
Historique:
entrez: 25 5 2022
pubmed: 26 5 2022
medline: 26 5 2022
Statut: epublish

Résumé

We isolated a SARS-CoV-2 BA.2 variant from a person with COVID-19 recrudescence after nirmatrelvir/ritonavir treatment. Antiviral sensitivity and neutralizing antibody testing was performed and compared with parental SARS-CoV-2 and multiple variants of concern. We found that neither NM resistance nor absence of neutralizing immunity were likely causes of the recrudescence.

Identifiants

pubmed: 35611335
doi: 10.21203/rs.3.rs-1662783/v1
pmc: PMC9128786
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : NIAID NIH HHS
ID : K08 AI130381
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131385
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI036214
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA055491
Pays : United States

Commentaires et corrections

Type : UpdateIn

Références

N Engl J Med. 2022 Apr 14;386(15):1397-1408
pubmed: 35172054

Auteurs

Aaron F Carlin (AF)

UC San Diego.

Alex E Clark (AE)

UC San Diego.

William Bray (W)

UC San Diego.

Magali Porrachi (M)

UC San Diego.

AsherLev T Santos (AT)

California State University San Marcos.

Davey M Smith (DM)

UC San Diego.

Classifications MeSH