Biomechanical Effects of Chronic Ankle Instability on the Talar Cartilage Matrix: The Value of T1ρ Relaxation Mapping Without and With Mechanical Loading.
T1ρ relaxation
cartilage degeneration
chronic ankle instability
in situ loading
magnetic resonance imaging
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
02 2023
02 2023
Historique:
revised:
10
05
2022
received:
08
02
2022
accepted:
11
05
2022
pubmed:
26
5
2022
medline:
20
1
2023
entrez:
25
5
2022
Statut:
ppublish
Résumé
T1ρ mapping has been proposed for the detection of early cartilage degeneration associated with chronic ankle instability (CAI). However, there are limited data surrounding the influence of ankle loading on T1ρ relaxation. To evaluate T1ρ relaxation times of talar cartilage, as an indicator of early degenerative changes, associated with CAI and to investigate the influence of acute axial in situ loading on T1ρ values in CAI patients and healthy controls. Prospective. A total of 9 patients (age = 21.8 ± 2.5 years, male/female = 2/7) with chronic ankle instability and 18 healthy control subjects (age = 22.8 ± 3.6 years, male/female = 5/13). 3 T. 3D gradient echo fast low-angle shot (FLASH) sequence augmented with a variable spin-lock preparation period. Ankle T1ρ mapping was performed without and with axial loading of 500 N. The talar cartilage was segmented in five coronal slices covering the central talocrural joint. Median talar T1ρ values were separately calculated for the medial and lateral facets. Mann-Whitney U and Wilcoxon signed-rank tests, significance level: P < 0.05. For the combined cohorts, the statistical analysis yielded significantly lower T1ρ values with loading compared to the no-load measurement for both the lateral (no load: [51.0 ± 4.0] msec, load: [49.5 ± 5.4] msec) as well as the medial compartment (no load: [50.0 ± 5.4] msec, load: [47.8 ± 6.8] msec). In the unloaded scans, the CAI patients showed significantly increased talar T1ρ values ([53.0 ± 7.4] mse ) compared to the healthy control subjects ([48.8 ± 4.1] msec) in the medial compartment. Increased talar T1ρ relaxation times in CAI patients compared to healthy controls suggest that T1ρ relaxation is a sensitive biomarker for CAI-induced early-stage cartilage degeneration. However, the load-induced T1ρ change did not prove to be a viable marker for the altered biomechanical properties of the hyaline talar cartilage. 2 LEVEL OF EFFICACY: Stage 2.
Sections du résumé
BACKGROUND
T1ρ mapping has been proposed for the detection of early cartilage degeneration associated with chronic ankle instability (CAI). However, there are limited data surrounding the influence of ankle loading on T1ρ relaxation.
PURPOSE
To evaluate T1ρ relaxation times of talar cartilage, as an indicator of early degenerative changes, associated with CAI and to investigate the influence of acute axial in situ loading on T1ρ values in CAI patients and healthy controls.
STUDY TYPE
Prospective.
SUBJECTS
A total of 9 patients (age = 21.8 ± 2.5 years, male/female = 2/7) with chronic ankle instability and 18 healthy control subjects (age = 22.8 ± 3.6 years, male/female = 5/13).
FIELD STRENGTH
3 T.
SEQUENCE
3D gradient echo fast low-angle shot (FLASH) sequence augmented with a variable spin-lock preparation period.
ASSESSMENT
Ankle T1ρ mapping was performed without and with axial loading of 500 N. The talar cartilage was segmented in five coronal slices covering the central talocrural joint. Median talar T1ρ values were separately calculated for the medial and lateral facets.
STATISTICAL TESTS
Mann-Whitney U and Wilcoxon signed-rank tests, significance level: P < 0.05.
RESULTS
For the combined cohorts, the statistical analysis yielded significantly lower T1ρ values with loading compared to the no-load measurement for both the lateral (no load: [51.0 ± 4.0] msec, load: [49.5 ± 5.4] msec) as well as the medial compartment (no load: [50.0 ± 5.4] msec, load: [47.8 ± 6.8] msec). In the unloaded scans, the CAI patients showed significantly increased talar T1ρ values ([53.0 ± 7.4] mse ) compared to the healthy control subjects ([48.8 ± 4.1] msec) in the medial compartment.
DATA CONCLUSION
Increased talar T1ρ relaxation times in CAI patients compared to healthy controls suggest that T1ρ relaxation is a sensitive biomarker for CAI-induced early-stage cartilage degeneration. However, the load-induced T1ρ change did not prove to be a viable marker for the altered biomechanical properties of the hyaline talar cartilage.
LEVEL OF EVIDENCE
2 LEVEL OF EFFICACY: Stage 2.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
611-619Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2022 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.
Références
de Noronha M, Refshauge KM, Herbert RD, Kilbreath SL. Do voluntary strength, proprioception, range of motion, or postural sway predict occurrence of lateral ankle sprain? Br J Sports Med 2006;40:824-828.
Doherty C, Bleakley C, Hertel J, Caulfield B, Ryan J, Delahunt E. Recovery from a first-time lateral ankle sprain and the predictors of chronic ankle instability: A prospective cohort analysis. Am J Sports Med 2016;44:995-1003.
Hertel J. Functional anatomy, pathomechanics, and pathophysiology of lateral ankle instability. J Athl Train 2002;37:364-375.
Caputo AM, Lee JY, Spritzer CE, et al. In vivo kinematics of the tibiotalar joint after lateral ankle instability. Am J Sports Med 2009;37:2241-2248.
Valderrabano V, Hintermann B, Horisberger M, Fung TS. Ligamentous posttraumatic ankle osteoarthritis. Am J Sports Med 2006;34:612-620.
Marinetti A, Tessarolo F, Ventura L, et al. Morphological MRI of knee cartilage: Repeatability and reproducibility of damage evaluation and correlation with gross pathology examination. Eur Radiol 2020;30:3226-3235.
Zhang M, Min Z, Rana N, Liu H. Accuracy of magnetic resonance imaging in grading knee chondral defects. Arthrosc J Arthrosc Relat Surg 2013;29:349-356.
Schreiner MM, Mlynarik V, Zbýň Š, et al. New technology in imaging cartilage of the ankle. Cartilage 2017;8:31-41.
Burstein D, Velyvis J, Scott KT, et al. Protocol issues for delayed Gd(DTPA)(2-)-enhanced MRI (dGEMRIC) for clinical evaluation of articular cartilage. Magn Reson Med 2001;45:36-41.
Abrar DB, Schleich C, Radke KL, et al. Detection of early cartilage degeneration in the tibiotalar joint using 3 T gagCEST imaging: A feasibility study. Magn Reson Mater Phys Biol Med 2021;34:249-260.
Raya JG. Techniques and applications of in vivo diffusion imaging of articular cartilage: Techniques of DTI of articular cartilage. J Magn Reson Imaging 2015;41:1487-1504.
Keenan KE, Besier TF, Pauly JM, et al. Prediction of glycosaminoglycan content in human cartilage by age, T1ρ and T2 MRI. Osteoarthr Cartil 2011;19:171-179.
Regatte RR, Akella SV, Lonner JH, Kneeland JB, Reddy R. T1rho relaxation mapping in human osteoarthritis (OA) cartilage: Comparison of T1rho with T2. J Magn Reson Imaging 2006;23:547-553.
Sasho T, Katsuragi J, Yamaguchi S, et al. Associations of three-dimensional T1 rho MR mapping and three-dimensional T2 mapping with macroscopic and histologic grading as a biomarker for early articular degeneration of knee cartilage. Clin Rheumatol 2017;36:2109-2119.
Ling W, Regatte RR, Navon G, Jerschow A. Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST). Proc Natl Acad Sci 2008;105:2266-2270.
Wikstrom EA, Song K, Tennant JN, Dederer KM, Paranjape C, Pietrosimone B. T1ρ MRI of the talar articular cartilage is increased in those with chronic ankle instability. Osteoarthr Cartil 2019;27:646-649.
Song K, Pietrosimone B, Tennant JN, et al. Talar and subtalar T1ρ relaxation times in limbs with and without chronic ankle instability. Cartilage 2021;13(1 Suppl):1402S-1410S.
Nieminen MT, Töyräs J, Laasanen MS, Silvennoinen J, Helminen HJ, Jurvelin JS. Prediction of biomechanical properties of articular cartilage with quantitative magnetic resonance imaging. J Biomech 2004;37:321-328.
Subburaj K, Kumar D, Souza RB, et al. The acute effect of running on knee articular cartilage and meniscus magnetic resonance relaxation times in young healthy adults. Am J Sports Med 2012;40:2134-2141.
Nag D, Liney GP, Gillespie P, Sherman KP. Quantification of T2 relaxation changes in articular cartilage with in situ mechanical loading of the knee. J Magn Reson Imaging 2004;19:317-322.
Nishii T, Kuroda K, Matsuoka Y, Sahara T, Yoshikawa H. Change in knee cartilage T2 in response to mechanical loading. J Magn Reson Imaging 2008;28:175-180.
Souza RB, Kumar D, Calixto N, et al. Response of knee cartilage T1rho and T2 relaxation times to in vivo mechanical loading in individuals with and without knee osteoarthritis. Osteoarthr Cartil 2014;22:1367-1376.
Lange T, Knowles BR, Herbst M, Izadpanah K, Zaitsev M. Comparative T2 and T1ρ mapping of patellofemoral cartilage under in situ mechanical loading with prospective motion correction: T2 and T1ρ mapping of knee cartilage. J Magn Reson Imaging 2017;46:452-460.
Wenning M, Gehring D, Lange T, et al. Clinical evaluation of manual stress testing, stress ultrasound and 3D stress MRI in chronic mechanical ankle instability. BMC Musculoskelet Disord 2021;22:198.
Gribble PA, Delahunt E, Bleakley CM, et al. Selection criteria for patients with chronic ankle instability in controlled research: A position statement of the international ankle consortium. J Athl Train 2014;49:121-127.
Hiller CE, Refshauge KM, Bundy AC, Herbert RD, Kilbreath SL. The Cumberland ankle instability tool: A report of validity and reliability testing. Arch Phys Med Rehabil 2006;87:1235-1241.
Witschey WRT, Borthakur A, Elliott MA, et al. Artifacts in T1ρ-weighted imaging: Compensation for B1 and B0 field imperfections. J Magn Reson 2007;186:75-85.
Li X, Han ET, Busse RF, Majumdar S. In vivoT1ρ mapping in cartilage using 3D magnetization-prepared angle-modulated partitionedk-space spoiled gradient echo snapshots (3D MAPSS). Magn Reson Med 2008;59:298-307.
Duvvuri U, Goldberg AD, Kranz JK, et al. Water magnetic relaxation dispersion in biological systems: The contribution of proton exchange and implications for the noninvasive detection of cartilage degradation. Proc Natl Acad Sci 2001;98:12479-12484.
Witschey WR, Borthakur A, Fenty M, et al. T1rho MRI quantification of arthroscopically confirmed cartilage degeneration. Magn Reson Med 2010;63:1376-1382.
Park SY, Yoon YC, Cha JG, Sung KS. T2 relaxation values of the Talar trochlear articular cartilage: Comparison between patients with lateral instability of the ankle joint and healthy volunteers. Am J Roentgenol 2016;206:136-143.
Tao H, Hu Y, Qiao Y, et al. T2 -mapping evaluation of early cartilage alteration of talus for chronic lateral ankle instability with isolated anterior talofibular ligament tear or combined with calcaneofibular ligament tear. J Magn Reson Imaging 2018;47:69-77.
Golditz T, Steib S, Pfeifer K, et al. Functional ankle instability as a risk factor for osteoarthritis: Using T2-mapping to analyze early cartilage degeneration in the ankle joint of young athletes. Osteoarthr Cartil 2014;22:1377-1385.
Taga I, Shino K, Inoue M, Nakata K, Maeda A. Articular cartilage lesions in ankles with lateral ligament injury: An arthroscopic study. Am J Sports Med 1993;21:120-127.
Hirose K, Murakami G, Minowa T, Kura H, Yamashita T. Lateral ligament injury of the ankle and associated articular cartilage degeneration in the talocrural joint: Anatomic study using elderly cadavers. J Orthop Sci off J Jpn Orthop Assoc 2004;9:37-43.
Noguchi K. Biomechanical analysis for osteoarthritis of the ankle. Nihon Seikeigeka Gakkai Zasshi 1985;59:215-222.
Shao H, Pauli C, Li S, et al. Magic angle effect plays a major role in both T1rho and T2 relaxation in articular cartilage. Osteoarthr Cartil 2017;25:2022-2030.
Horiuchi S, Yu HJ, Luk A, et al. T1rho and T2 mapping of ankle cartilage of female and male ballet dancers. Acta Radiol Stockh Swed 1987;2020(61):1365-1376.
Lange T, Maclaren J, Herbst M, Lovell-Smith C, Izadpanah K, Zaitsev M. Knee cartilage MRI with in situ mechanical loading using prospective motion correction: Knee cartilage MRI using prospective motion correction. Magn Reson Med 2014;71:516-523.
Hosseini A, Van de Velde SK, Kozanek M, et al. In-vivo time-dependent articular cartilage contact behavior of the tibiofemoral joint. Osteoarthr Cartil 2010;18:909-916.