Autologous simple conjunctival epithelial transplantation for primary pterygium.
Adjuvant treatment
Conjunctival surgery
Primary pterygium
Recurrence
Simple conjunctival epithelial transplantation
Journal
International ophthalmology
ISSN: 1573-2630
Titre abrégé: Int Ophthalmol
Pays: Netherlands
ID NLM: 7904294
Informations de publication
Date de publication:
Dec 2022
Dec 2022
Historique:
received:
14
07
2021
accepted:
28
04
2022
pubmed:
26
5
2022
medline:
2
11
2022
entrez:
25
5
2022
Statut:
ppublish
Résumé
To evaluate the feasibility of a new method of conjunctival transplantation to achieve recovery of the normal conjunctival epithelium over the bare sclera after pterygium excision and prevent its recurrence. After excision of the primary pterygium, we performed simple conjunctival epithelial transplantation (SCET) in which we glued an amniotic membrane patch pre-loaded with tiny autologous conjunctival tissue fragments over the scleral defect. Slit-lamp evaluation was performed at 2 and 7-10 days, and then at 1, 3, 6, and 12 months after surgery, together with confocal microscopy at 3, 6, and 12 months. Surgical excision and SCET for nasal primary pterygium were performed in 6 eyes (6 patients). No graft detachment occurred. An inflammatory granuloma was excised without sequelae in one patient 2 months after surgery. No signs of recurrence or sight-threatening complications were recorded at 12 months, and in vivo confocal microscopy showed progressive expansion of the conjunctival cell population and formation of a clear corneal-conjunctival transition. SCET takes advantage of the ability of the amniotic membrane and conjunctival cells to renew. Outcomes after SCET are comparable to conventional conjunctival flap surgery and can be achieved in less surgical time and with less donor tissue to be removed.
Identifiants
pubmed: 35612687
doi: 10.1007/s10792-022-02364-9
pii: 10.1007/s10792-022-02364-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3673-3680Subventions
Organisme : the italian ministry of health and the italian ministry of university and research
ID : 5 x 1000
Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer Nature B.V.
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