The translational challenge in Chagas disease drug development.
Journal
Memorias do Instituto Oswaldo Cruz
ISSN: 1678-8060
Titre abrégé: Mem Inst Oswaldo Cruz
Pays: Brazil
ID NLM: 7502619
Informations de publication
Date de publication:
2022
2022
Historique:
received:
26
09
2020
accepted:
13
01
2021
entrez:
25
5
2022
pubmed:
26
5
2022
medline:
28
5
2022
Statut:
epublish
Résumé
Chagas disease is a neglected tropical disease caused by the protozoan parasite Trypanosoma cruzi. There is an urgent need for safe, effective, and accessible new treatments since the currently approved drugs have serious limitations. Drug development for Chagas disease has historically been hampered by the complexity of the disease, critical knowledge gaps, and lack of coordinated R&D efforts. This review covers some of the translational challenges associated with the progression of new chemical entities from preclinical to clinical phases of development, and discusses how recent technological advances might allow the research community to answer key questions relevant to the disease and to overcome hurdles in R&D for Chagas disease.
Identifiants
pubmed: 35613156
pii: S0074-02762022000100206
doi: 10.1590/0074-02760200501
pmc: PMC9128742
pii:
doi:
Substances chimiques
Trypanocidal Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e200501Commentaires et corrections
Type : CommentIn
Type : CommentIn
Références
Infect Genet Evol. 2020 Mar;78:104128
pubmed: 31786340
Acta Trop. 2018 Aug;184:38-52
pubmed: 28941731
Antimicrob Agents Chemother. 2015 Aug;59(8):4653-61
pubmed: 26014936
Nat Rev Drug Discov. 2017 Aug;16(8):531-543
pubmed: 28685762
mBio. 2020 Aug 4;11(4):
pubmed: 32753495
Nature. 2018 Jul;559(7715):498-506
pubmed: 30046073
BMC Genomics. 2018 Nov 13;19(1):816
pubmed: 30424726
Semin Immunopathol. 2020 Jun;42(3):231-246
pubmed: 32189034
ACS Infect Dis. 2019 Feb 8;5(2):152-157
pubmed: 30543391
Parasitol Int. 2010 Dec;59(4):565-70
pubmed: 20688189
Curr Opin Infect Dis. 2006 Dec;19(6):583-7
pubmed: 17075335
Expert Rev Clin Pharmacol. 2018 Oct;11(10):943-957
pubmed: 30111183
Trans R Soc Trop Med Hyg. 1987;81(5):755-9
pubmed: 3130683
Lancet. 2018 Jan 6;391(10115):82-94
pubmed: 28673423
Microb Genom. 2018 May;4(5):
pubmed: 29708484
Parasitology. 2017 Dec;144(14):1871-1880
pubmed: 28831944
Elife. 2018 Mar 26;7:
pubmed: 29578409
Sci Rep. 2015 Mar 05;5:8771
pubmed: 25740547
PLoS One. 2014 Feb 04;9(2):e87188
pubmed: 24503652
PLoS Negl Trop Dis. 2018 Jul 12;12(7):e0006612
pubmed: 30001347
Cell. 2020 Jan 23;180(2):359-372.e16
pubmed: 31955846
Nat Rev Microbiol. 2017 Feb 27;15(4):217-231
pubmed: 28239154
Trends Parasitol. 2016 Nov;32(11):899-911
pubmed: 27612651
Nat Rev Drug Discov. 2015 Nov;14(11):751-8
pubmed: 26435527
Nat Rev Microbiol. 2007 Jan;5(1):48-56
pubmed: 17143318
Drug Dev Res. 2022 Apr;83(2):225-252
pubmed: 32249457
PLoS Pathog. 2015 Jul 17;11(7):e1005058
pubmed: 26186534
Clin Microbiol Rev. 2011 Jul;24(3):592-630
pubmed: 21734249
BMC Biotechnol. 2006 Jul 06;6:32
pubmed: 16824206
mBio. 2017 Nov 7;8(6):
pubmed: 29114029
PLoS Negl Trop Dis. 2020 Apr 23;14(4):e0008035
pubmed: 32324735
PLoS Negl Trop Dis. 2015 Jan 23;9(1):e0003493
pubmed: 25615687
Sci Rep. 2014 Apr 16;4:4703
pubmed: 24736467
PLoS Pathog. 2014 May 01;10(5):e1004114
pubmed: 24789335
Commun Biol. 2020 Jan 3;3:7
pubmed: 31909199
Int J Parasitol Drugs Drug Resist. 2020 Aug;13:107-120
pubmed: 32688218
Nat Rev Drug Discov. 2011 Jun 24;10(7):507-19
pubmed: 21701501
Drug Des Devel Ther. 2015 Aug 19;9:4807-23
pubmed: 26316715
Mem Inst Oswaldo Cruz. 2010 Mar;105(2):233-8
pubmed: 20428688
Nat Rev Microbiol. 2019 Oct;17(10):607-620
pubmed: 31444481
PLoS Negl Trop Dis. 2018 Nov 12;12(11):e0006939
pubmed: 30418976
Antimicrob Agents Chemother. 1996 Nov;40(11):2592-7
pubmed: 8913471
Expert Opin Drug Discov. 2017 May;12(5):427-429
pubmed: 28306350
J Biomol Screen. 2015 Jan;20(1):22-35
pubmed: 25245987
PLoS Negl Trop Dis. 2015 Nov 20;9(11):e0004194
pubmed: 26587586
PLoS Negl Trop Dis. 2016 Dec 16;10(12):e0005181
pubmed: 27984589
N Engl J Med. 2014 May 15;370(20):1899-908
pubmed: 24827034
Int J Parasitol Drugs Drug Resist. 2016 Dec;6(3):165-170
pubmed: 27639944
PLoS Negl Trop Dis. 2009 Jul 07;3(7):e488
pubmed: 19582142
Acta Trop. 2019 Oct;198:105107
pubmed: 31351074
Sci Rep. 2016 Oct 17;6:35351
pubmed: 27748443
Lancet Infect Dis. 2018 Apr;18(4):419-430
pubmed: 29352704
J Am Coll Cardiol. 2017 Feb 28;69(8):939-947
pubmed: 28231946
Trop Med Infect Dis. 2019 May 17;4(2):
pubmed: 31108888
Cell Microbiol. 2014 Sep;16(9):1285-300
pubmed: 24712539
Antimicrob Agents Chemother. 2010 Aug;54(8):3326-34
pubmed: 20547819
ACS Infect Dis. 2020 Mar 13;6(3):515-528
pubmed: 31967783
Int J Parasitol. 2008 Oct;38(12):1391-400
pubmed: 18511053
Nature. 2016 Sep 8;537(7619):229-233
pubmed: 27501246
PLoS Negl Trop Dis. 2016 Apr 15;10(4):e0004584
pubmed: 27082760
Mem Inst Oswaldo Cruz. 2015 May;110(3):277-82
pubmed: 25466622
Curr Top Med Chem. 2011;11(10):1275-83
pubmed: 21401506
Mem Inst Oswaldo Cruz. 2014 Sep;109(6):828-33
pubmed: 25317712
Expert Opin Drug Discov. 2020 Dec;15(12):1381-1402
pubmed: 32812830
Osteoarthritis Cartilage. 2017 Mar;25(3):354-363
pubmed: 27816577