Size-tunable PEG-grafted copolymers as a polymeric nanoruler for passive targeting muscle tissues.

Animals Mice Mice, Inbred mdx Muscle, Skeletal / metabolism Polyethylene Glycols / chemistry Polymers / metabolism Tissue Distribution
Graft copolymer Muscle targeting Muscular dystrophy PEG Size effect

Journal

Journal of controlled release : official journal of the Controlled Release Society
ISSN: 1873-4995
Titre abrégé: J Control Release
Pays: Netherlands
ID NLM: 8607908

Informations de publication

Date de publication:
07 2022
Historique:
received: 14 04 2022
revised: 14 05 2022
accepted: 18 05 2022
pubmed: 26 5 2022
medline: 29 6 2022
entrez: 25 5 2022
Statut: ppublish

Résumé

Muscle-targeted drug delivery is a major challenge in nanomedicine. The extravasation of nanomedicines (or nanoparticles) from the bloodstream into muscle tissues is hindered by the continuous endothelium, the so-called blood-muscle barrier. This study aimed to evaluate the optimal size of macromolecular drugs for extravasation (or passive targeting) into muscle tissues. We constructed a size-tunable polymeric delivery platform as a polymeric nanoruler by grafting poly(ethylene glycol)s (PEGs) onto the poly(aspartic acid) (PAsp) backbone. A series of PEG-grafted copolymers (gPEGs) with a narrow size distribution between 11 and 32 nm in hydrodynamic diameter (D

Identifiants

DOI: 10.1016/j.jconrel.2022.05.030 PMID: 35613686
pubmed: 35613686
pii: S0168-3659(22)00301-7
doi: 10.1016/j.jconrel.2022.05.030
pii:
doi:

Substances chimiques

Polymers 0
Polyethylene Glycols 3WJQ0SDW1A

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

607-614

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Mitsuru Naito (M)

Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Japan. Electronic address: naito@bmw.t.u-tokyo.ac.jp.

Yusuke Watanuki (Y)

Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Japan.

Kazuko Toh (K)

Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan.

Jongmin Yum (J)

Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Japan.

Beob Soo Kim (BS)

Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Japan.

Kaori Taniwaki (K)

Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Japan.

Satomi Ogura (S)

Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Japan.

Hiroki Ishida (H)

Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Japan.

Masaru Cho (M)

Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Japan.

Hiroyuki Chaya (H)

Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Japan.

Ken Miyajima (K)

Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Japan.

Yuichi Yamasaki (Y)

Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Japan.

Kensuke Osada (K)

Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba 263-8555, Japan.

Katsura Minegishi (K)

Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi-cho, Kodaira, Tokyo 187-8551, Japan.

Yoshitsugu Aoki (Y)

Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-higashi-cho, Kodaira, Tokyo 187-8551, Japan.

Kanjiro Miyata (K)

Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8656, Japan. Electronic address: miyata@bmw.t.u-tokyo.ac.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Size-tunable PEG-grafted copolymers as a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Size-tunable PEG-grafted copolymers as a...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souches mutantes de souris › Souris de lignée mdx › Size-tunable PEG-grafted copolymers as a...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Muscles squelettiques › Size-tunable PEG-grafted copolymers as a...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyéthylène glycols › Size-tunable PEG-grafted copolymers as a...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Size-tunable PEG-grafted copolymers as a...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Distribution tissulaire › Size-tunable PEG-grafted copolymers as a...