Alpha- and Gamma-Tocopherol Modulates the Amyloidogenic Pathway of Amyloid Precursor Protein in an
APP–amyloid precursor protein
Alzheimer’s disease
amyloid beta
gene expression
tocopherol isomers
Journal
Frontiers in cellular neuroscience
ISSN: 1662-5102
Titre abrégé: Front Cell Neurosci
Pays: Switzerland
ID NLM: 101477935
Informations de publication
Date de publication:
2022
2022
Historique:
received:
31
12
2021
accepted:
15
02
2022
entrez:
26
5
2022
pubmed:
27
5
2022
medline:
27
5
2022
Statut:
epublish
Résumé
The amyloid precursor protein (APP) processing pathway was altered in Alzheimer's disease (AD) and contributed to abnormal amyloid-beta (Aβ) production, which forms insoluble interneuron protein aggregates known as amyloid plaques in the brain. Targeting the APP processing pathway is still fundamental for AD modifying therapy. Extensive research has evaluated the protective effects of vitamin E as an antioxidant and as a signaling molecule. The present study aimed to investigate the modulatory effects of different tocopherol isomers on the expression of genes involved in regulating the APP processing pathway
Identifiants
pubmed: 35614968
doi: 10.3389/fncel.2022.846459
pmc: PMC9125555
doi:
Types de publication
Journal Article
Langues
eng
Pagination
846459Informations de copyright
Copyright © 2022 Pahrudin Arrozi, Shukri, Mohd Murshid, Ahmad Shahzalli, Wan Ngah, Ahmad Damanhuri and Makpol.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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