Epidemiological and Clinical Characteristics of Pediatric COVID-19 in the Tertiary Care System in Thailand: Comparative Delta and pre-Delta Era.
COVID-19
Delta
Pediatric
SARS-CoV-2
Journal
Mediterranean journal of hematology and infectious diseases
ISSN: 2035-3006
Titre abrégé: Mediterr J Hematol Infect Dis
Pays: Italy
ID NLM: 101530512
Informations de publication
Date de publication:
2022
2022
Historique:
received:
17
02
2022
accepted:
15
04
2022
entrez:
26
5
2022
pubmed:
27
5
2022
medline:
27
5
2022
Statut:
epublish
Résumé
Few studies had focused on the epidemiological and clinical characteristics of pediatric COVID-19 (SARS-CoV-2) during Delta and pre-Delta eras in Asia, despite it being a pandemic. To study the epidemiological and clinical characteristics of three waves of pediatric COVID-19 infections in a tertiary-care setting in Thailand. This retrospective study reviewed all PCR-confirmed pediatric (0-18 years of age) COVID-19 infections between January 13, 2020, and October 31, 2021, in a tertiary care system in Thailand. 1,019 patients, aged 0.02 - 18 years, 552 (54.2%) male, and 467 (45.8%) female, with a median age of 9.2 years, were enrolled. Asymptomatic cases accounted for 35.7%, of which 106 (18.9%) had abnormal chest X-ray findings. Most cases were classified as having mild clinical symptoms, with only 8 (0.8%) and 4 (0.4%) developing a severe and critical illness, respectively. There were no deaths. The Delta variant appeared more transmissible than previous ones, but we did not see any difference in disease severity. Upper respiratory tract symptoms were predominant, while few cases had lower respiratory tract involvement. The sensitivity and specificity of dyspnea symptoms to predict radiologically confirmed pneumonia were 14% and 95%, respectively, with a likelihood ratio of 3.37. The overall prognosis was good, with only 13 (1.3 %) needing respiratory support. All cases showed clinical improvement with a decent recovery. Pediatric COVID-19 during the Delta variant predominance era generally appeared more transmissible but benign. One-fifth of cases had pneumonia, but few cases needed respiratory support. Prevention remains important for disease control.
Sections du résumé
Background
UNASSIGNED
Few studies had focused on the epidemiological and clinical characteristics of pediatric COVID-19 (SARS-CoV-2) during Delta and pre-Delta eras in Asia, despite it being a pandemic.
Objective
UNASSIGNED
To study the epidemiological and clinical characteristics of three waves of pediatric COVID-19 infections in a tertiary-care setting in Thailand.
Methods
UNASSIGNED
This retrospective study reviewed all PCR-confirmed pediatric (0-18 years of age) COVID-19 infections between January 13, 2020, and October 31, 2021, in a tertiary care system in Thailand.
Results
UNASSIGNED
1,019 patients, aged 0.02 - 18 years, 552 (54.2%) male, and 467 (45.8%) female, with a median age of 9.2 years, were enrolled. Asymptomatic cases accounted for 35.7%, of which 106 (18.9%) had abnormal chest X-ray findings. Most cases were classified as having mild clinical symptoms, with only 8 (0.8%) and 4 (0.4%) developing a severe and critical illness, respectively. There were no deaths. The Delta variant appeared more transmissible than previous ones, but we did not see any difference in disease severity. Upper respiratory tract symptoms were predominant, while few cases had lower respiratory tract involvement. The sensitivity and specificity of dyspnea symptoms to predict radiologically confirmed pneumonia were 14% and 95%, respectively, with a likelihood ratio of 3.37. The overall prognosis was good, with only 13 (1.3 %) needing respiratory support. All cases showed clinical improvement with a decent recovery.
Conclusion
UNASSIGNED
Pediatric COVID-19 during the Delta variant predominance era generally appeared more transmissible but benign. One-fifth of cases had pneumonia, but few cases needed respiratory support. Prevention remains important for disease control.
Identifiants
pubmed: 35615321
doi: 10.4084/MJHID.2022.044
pii: mjhid-14-1-e2022044
pmc: PMC9084174
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e2022044Déclaration de conflit d'intérêts
Competing interests: The authors declare no conflict of Interest.
Références
EClinicalMedicine. 2020 Jun 26;24:100433
pubmed: 32766542
J Infect Public Health. 2020 May;13(5):667-673
pubmed: 32340833
MMWR Morb Mortal Wkly Rep. 2020 Apr 10;69(14):422-426
pubmed: 32271728
J Clin Virol. 2021 Feb;135:104715
pubmed: 33348220
Ann Transl Med. 2020 May;8(10):620
pubmed: 32566557
Radiol Cardiothorac Imaging. 2020 Apr 23;2(2):e200214
pubmed: 33778577
Front Pediatr. 2020 Jul 03;8:431
pubmed: 32719759
N Engl J Med. 2020 Feb 20;382(8):727-733
pubmed: 31978945
Emerg Infect Dis. 2020 Jul;26(7):1580-1585
pubmed: 32267826
BMC Med. 2020 Aug 6;18(1):250
pubmed: 32762696
Pediatrics. 2020 Jun;145(6):
pubmed: 32179660
JPEN J Parenter Enteral Nutr. 2013 Jul;37(4):460-81
pubmed: 23528324
PLoS One. 2020 Sep 15;15(9):e0239250
pubmed: 32931517
MMWR Morb Mortal Wkly Rep. 2021 Sep 10;70(36):1255-1260
pubmed: 34499627
Pediatr Infect Dis J. 2022 Jan 1;41(1):e34-e35
pubmed: 34773397
Am J Trop Med Hyg. 2021 Jun 15;105(2):413-420
pubmed: 34129517
Bull World Health Organ. 2007 Sep;85(9):660-7
pubmed: 18026621
Arch Dis Child. 2021 Feb 16;:
pubmed: 33593743
J Allergy Clin Immunol Pract. 2020 Jun;8(6):2118-2120
pubmed: 33427648